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Literature summary extracted from

  • Plumbridge, J.
    An alternative route for recycling of N-acetylglucosamine from peptidoglycan involves the N-acetylglucosamine phosphotransferase system in Escherichia coli (2009), J. Bacteriol., 191, 5641-5647.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.193 expressed in Escherichia coli IBPC590 cells Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.25 additional information mutations in nagA result in accumulation of millimolar of N-acetylglucosamine, presumably by preventing peptidoglycan recycling. Mutations in the genes encoding the key enzymes upstream of nagA in the recycling pathway (amG, nagZ, nagK, murQ, and anmK), which are expected to interrupt the recycling process, reduce but do not eliminate accumulation of N-acetyl-6-phosphate Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.193 [protein]-Npi-phospho-L-histidine + N-acetyl-D-glucosamine[side 1] Escherichia coli
-
 [protein]-L-histidine + N-acetyl-D-glucosamine 6-phosphate[side2]
-
 ?
2.7.1.193 [protein]-Npi-phospho-L-histidine + N-acetyl-D-glucosamine[side 1] Escherichia coli JW0662
-
 [protein]-L-histidine + N-acetyl-D-glucosamine 6-phosphate[side2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.193 Escherichia coli
-
-
-
2.7.1.193 Escherichia coli JW0662
-
-
-
3.5.1.25 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.193 [protein]-Npi-phospho-L-histidine + N-acetyl-D-glucosamine[side 1]
-
 Escherichia coli [protein]-L-histidine + N-acetyl-D-glucosamine 6-phosphate[side2]
-
 ?
2.7.1.193 [protein]-Npi-phospho-L-histidine + N-acetyl-D-glucosamine[side 1]
-
 Escherichia coli JW0662 [protein]-L-histidine + N-acetyl-D-glucosamine 6-phosphate[side2]
-
 ?
3.5.1.25 N-acetyl-D-glucosamine 6-phosphate + H2O
-
 Escherichia coli D-glucosamine 6-phosphate + acetate
-
 ?
3.5.1.25 N-acetyl-D-glucosamine 6-phosphate + H2O
-
 Escherichia coli JW0662 D-glucosamine 6-phosphate + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.193 GlcNAc6P-specific transporter of the GlcNAc PTS
-
 Escherichia coli
2.7.1.193 nagE
-
 Escherichia coli
3.5.1.25 NagA
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.7.1.193 metabolism the nagE-encoded enzyme makes an important contribution to the recycling of peptidoglycan Escherichia coli
3.5.1.25 physiological function part of the pathway responsible for the recycling of amino sugar components of peptidoglycan, the cataboloc pathway for the use of N-acetylglucosamine Escherichia coli