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Literature summary extracted from

  • Zhang, L.; Shen, Y.; Zhu, H.J.; Wang, F.; Leng, Y.; Liu, J.K.
    Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11beta-hydroxysteroid dehydrogenases inhibitory activity (2009), J. Antibiot., 62, 239-242.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.B40 expressed in HEK-293 cell Mus musculus
1.1.1.B40 expressed in HEK-293 cell Homo sapiens
1.1.1.146 expressed in HEK-293 cell Mus musculus
1.1.1.146 expressed in HEK-293 cell Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 (2S)-5-(acetyloxy)-2-hydroxypentyl acetate
-
 Homo sapiens
1.1.1.B40 2-oxopentane-1,5-diyl diacetate
-
 Homo sapiens
1.1.1.B40 2-oxopentane-1,5-diyl diacetate
-
 Mus musculus
1.1.1.B40 5-hydroxy-4-oxopentyl acetate
-
 Homo sapiens
1.1.1.B40 5-hydroxy-4-oxopentyl acetate
-
 Mus musculus
1.1.1.146 (2S)-5-(acetyloxy)-2-hydroxypentyl acetate
-
 Homo sapiens
1.1.1.146 2-oxopentane-1,5-diyl diacetate
-
 Homo sapiens
1.1.1.146 2-oxopentane-1,5-diyl diacetate
-
 Mus musculus
1.1.1.146 5-hydroxy-4-oxopentyl acetate
-
 Homo sapiens
1.1.1.146 5-hydroxy-4-oxopentyl acetate
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
-
-
1.1.1.B40 Mus musculus
-
-
-
1.1.1.146 Homo sapiens
-
-
-
1.1.1.146 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+
-
 Mus musculus cortisone + NADH + H+
-
 ?
1.1.1.B40 cortisol + NAD+
-
 Homo sapiens cortisone + NADH + H+
-
 ?
1.1.1.146 cortisone + NADPH + H+
-
 Mus musculus cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-hydroxysteroid dehydrogenase 2
-
 Mus musculus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase 2
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase 1
-
 Mus musculus
1.1.1.146 11beta-hydroxysteroid dehydrogenase 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Mus musculus
1.1.1.B40 NAD+
-
 Homo sapiens
1.1.1.146 NADP+
-
 Mus musculus
1.1.1.146 NADP+
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.B40 additional information
-
 IC50 = 0.0051 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-oxopentane-1,5-diyl diacetate
1.1.1.B40 additional information
-
 IC50 = 0.0323 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus 2-oxopentane-1,5-diyl diacetate
1.1.1.B40 additional information
-
 IC50 = 0.0389 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-hydroxy-4-oxopentyl acetate
1.1.1.B40 additional information
-
 IC50 = 0.1291 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus 5-hydroxy-4-oxopentyl acetate
1.1.1.B40 additional information
-
 IC50 = 0.177 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens (2S)-5-(acetyloxy)-2-hydroxypentyl acetate
1.1.1.146 additional information
-
 IC50 = 0.0287 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-oxopentane-1,5-diyl diacetate
1.1.1.146 additional information
-
 IC50 = 0.0304 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus 2-oxopentane-1,5-diyl diacetate
1.1.1.146 additional information
-
 IC50 = 0.0474 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-hydroxy-4-oxopentyl acetate
1.1.1.146 additional information
-
 IC50 = 0.0623 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens (2S)-5-(acetyloxy)-2-hydroxypentyl acetate
1.1.1.146 additional information
-
 IC50 = 0.1492 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus 5-hydroxy-4-oxopentyl acetate