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Literature summary extracted from

  • Yu, C.J.; Zheng, M.F.; Kuang, C.X.; Huang, W.D.; Yang, Q.
    Oren-gedoku-to and its constituents with therapeutic potential in Alzheimers disease inhibit indoleamine 2, 3-dioxygenase activity in vitro (2010), J. Alzheimers Dis., 22, 257-266.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-Methyltryptophan
-
 Homo sapiens
1.13.11.52 baicalein uncompetitive reversible potent IDO-1 inhibitor Homo sapiens
1.13.11.52 Berberine uncompetitive reversible potent IDO-1 inhibitor Homo sapiens
1.13.11.52 Jatrorrhizine irreversible potent IDO-1 inhibitor Homo sapiens
1.13.11.52 additional information the traditional Chinese medicinal prescription Oren-gedoku-to significantly inhibits recombinant human IDO-1 activity in vitro Homo sapiens
1.13.11.52 palmatine irreversible potent IDO-1 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO-1
-
 Homo sapiens
1.13.11.52 indoleamine 2, 3-dioxygenase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.52 0.008
-
 Berberine pH and temperature not specified in the publication Homo sapiens
1.13.11.52 0.215
-
 baicalein pH and temperature not specified in the publication Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.52 0.0093
-
 pH and temperature not specified in the publication Homo sapiens Berberine

General Information

EC Number General Information Comment Organism
1.13.11.52 physiological function IDO-1 is one of the key players involved in the pathogenesis of Alzheimer's disease Homo sapiens