BRENDA - Enzyme Database

Oren-gedoku-to and its constituents with therapeutic potential in Alzheimers disease inhibit indoleamine 2, 3-dioxygenase activity in vitro

Yu, C.J.; Zheng, M.F.; Kuang, C.X.; Huang, W.D.; Yang, Q.; J. Alzheimers Dis. 22, 257-266 (2010)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.13.11.52
1-Methyltryptophan
-
Homo sapiens
1.13.11.52
baicalein
uncompetitive reversible potent IDO-1 inhibitor
Homo sapiens
1.13.11.52
Berberine
uncompetitive reversible potent IDO-1 inhibitor
Homo sapiens
1.13.11.52
Jatrorrhizine
irreversible potent IDO-1 inhibitor
Homo sapiens
1.13.11.52
additional information
the traditional Chinese medicinal prescription Oren-gedoku-to significantly inhibits recombinant human IDO-1 activity in vitro
Homo sapiens
1.13.11.52
palmatine
irreversible potent IDO-1 inhibitor
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.13.11.52
L-tryptophan + O2
Homo sapiens
-
N-formyl-L-kynurenine
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.13.11.52
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.13.11.52
HEK-293 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.13.11.52
L-tryptophan + O2
-
712230
Homo sapiens
N-formyl-L-kynurenine
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.13.11.52
0.008
-
Berberine
pH and temperature not specified in the publication
Homo sapiens
1.13.11.52
0.215
-
baicalein
pH and temperature not specified in the publication
Homo sapiens
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
1.13.11.52
0.0093
-
pH and temperature not specified in the publication
Homo sapiens
Berberine
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
1.13.11.52
0.0093
-
pH and temperature not specified in the publication
Homo sapiens
Berberine
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.13.11.52
1-Methyltryptophan
-
Homo sapiens
1.13.11.52
baicalein
uncompetitive reversible potent IDO-1 inhibitor
Homo sapiens
1.13.11.52
Berberine
uncompetitive reversible potent IDO-1 inhibitor
Homo sapiens
1.13.11.52
Jatrorrhizine
irreversible potent IDO-1 inhibitor
Homo sapiens
1.13.11.52
additional information
the traditional Chinese medicinal prescription Oren-gedoku-to significantly inhibits recombinant human IDO-1 activity in vitro
Homo sapiens
1.13.11.52
palmatine
irreversible potent IDO-1 inhibitor
Homo sapiens
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.13.11.52
0.008
-
Berberine
pH and temperature not specified in the publication
Homo sapiens
1.13.11.52
0.215
-
baicalein
pH and temperature not specified in the publication
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.13.11.52
L-tryptophan + O2
Homo sapiens
-
N-formyl-L-kynurenine
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.13.11.52
HEK-293 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.13.11.52
L-tryptophan + O2
-
712230
Homo sapiens
N-formyl-L-kynurenine
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
1.13.11.52
physiological function
IDO-1 is one of the key players involved in the pathogenesis of Alzheimer's disease
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.13.11.52
physiological function
IDO-1 is one of the key players involved in the pathogenesis of Alzheimer's disease
Homo sapiens