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Literature summary extracted from

  • Tóth, I.; Szécsi, M.; Julesz, J.; Faredin, I.; Behnke, B.
    In vitro inhibition of testicular delta 5-3 beta-hydroxysteroid dehydrogenase and prostatic 5 alpha-reductase activities in rats and humans by strogen forte extract (1996), Int. Urol. Nephrol., 28, 337-348.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.51 medicine inhibitor Strogen forte extract can be used for treatment of benign prostatic hyperplasia Homo sapiens
1.3.99.5 medicine inhibitor Strogen forte extract can be used for treatment of benign prostatic hyperplasia Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.51 Strogen forte standardized extract of the plant Sabalis serrulata, 0.212 mg/ml result in 50% enzyme inhibition Homo sapiens
1.1.1.51 Strogen forte standardized extract of the plant Sabalis serrulata, 0.4 mg/ml result in 50% enzyme inhibition Rattus norvegicus
1.3.99.5 Strogen forte standardized extract of the plant Sabalis serrulata, 0.245 mg/ml result in 50% enzyme inhibition Homo sapiens
1.3.99.5 Strogen forte standardized extract of the plant Sabalis serrulata, 0.385 mg/ml result in 50% enzyme inhibition Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-
1.1.1.51 Rattus norvegicus
-
-
-
1.1.1.51 Rattus norvegicus Wistar
-
-
-
1.3.99.5 Homo sapiens
-
-
-
1.3.99.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 testis
-
 Homo sapiens
-
1.1.1.51 testis
-
 Rattus norvegicus
-
1.3.99.5 prostate gland
-
 Homo sapiens
-
1.3.99.5 prostate gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 dehydroepiandrosterone + NAD+
-
 Homo sapiens 4-androstene-3,17-dione + NADH + H+
-
 ?
1.1.1.51 dehydroepiandrosterone + NAD+
-
 Rattus norvegicus 4-androstene-3,17-dione + NADH + H+
-
 ?
1.1.1.51 dehydroepiandrosterone + NAD+
-
 Rattus norvegicus Wistar 4-androstene-3,17-dione + NADH + H+
-
 ?
1.3.99.5 testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
 ?
1.3.99.5 testosterone + NADPH + H+
-
 Rattus norvegicus 5alpha-dihydrotestosterone + NADP+
-
 ?
1.3.99.5 testosterone + NADPH + H+
-
 Rattus norvegicus Wistar 5alpha-dihydrotestosterone + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 DELTA5-3beta-HSD
-
 Homo sapiens
1.1.1.51 DELTA5-3beta-HSD
-
 Rattus norvegicus
1.3.99.5 5alpha-R
-
 Homo sapiens
1.3.99.5 5alpha-R
-
 Rattus norvegicus