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Literature summary extracted from

  • Gholamhoseinian, A.; Shahouzehi, B.; Sharifi-Far, F.
    Inhibitory activity of some plant methanol extracts on 3-hydroxy-3-methylglutaryl coenzyme A reductase (2010), Int. J. Pharmacol., 6, 705-711.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 additional information methanolic extracts of Quercus infectoria galls, Rosa damascena flowers, and Myrtus communis leaves inhibit the enzyme activity noncompetitively to 84%, 70%, and 62%, respectively. Extracts of diverse other plants are also inhibitory for the enzyme, detailed overview Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.34 0.6
-
3-hydroxy-3-methylglutaryl-CoA pH 7.5, temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Homo sapiens
-
mevalonate + CoA + 2 NADP+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 commercial preparation recombinant enzyme Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
Homo sapiens mevalonate + CoA + 2 NADP+
-
r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMG CoA reductase
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.34 7.5
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADP+
-
Homo sapiens
1.1.1.34 NADPH
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.34 additional information
-
additional information inhibition kinetics of different plant extracts, overview Homo sapiens