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Literature summary extracted from

  • Hayashi, A.; Horiuchi, A.; Kikuchi, N.; Hayashi, T.; Fuseya, C.; Suzuki, A.; Konishi, I.; Shiozawa, T.
    Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin (2010), Int. J. Cancer, 127, 1332-1346.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 apicidin
-
 Homo sapiens
3.5.1.98 suberoylanilide hydroxamic acid
-
 Homo sapiens
3.5.1.98 trichostatin A
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.98 cytoplasm cytoplasmic expression of HDAC1, 2 and 3 is significantly increased in carcinomas compared with benign tumors Homo sapiens 5737
-
3.5.1.98 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 A-2780 cell
-
 Homo sapiens
-
3.5.1.98 A2780/CDDP cell
-
 Homo sapiens
-
3.5.1.98 ES-2 cell
-
 Homo sapiens
-
3.5.1.98 IGROV-1 cell
-
 Homo sapiens
-
3.5.1.98 ovarian carcinoma cell
-
 Homo sapiens
-
3.5.1.98 OVCAR-3 cell
-
 Homo sapiens
-
3.5.1.98 SKOV-3 cell
-
 Homo sapiens
-
3.5.1.98 TOV-112D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 Fluor de Lys HDAC substrate + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC1
-
 Homo sapiens
3.5.1.98 HDAC2
-
 Homo sapiens
3.5.1.98 HDAC3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.5.1.98 Homo sapiens the immunohistochemical expression of nuclear HDAC1, HDAC2 and HDAC3 proteins increases stepwise in benign, borderline and malignant tumors of ovarian carcinoma. Cytoplasmic expression of HDAC1, 2 and 3 is significantly increased in carcinomas compared with benign tumors up

General Information

EC Number General Information Comment Organism
3.5.1.98 malfunction suppression of HDAC3 reduces the migration and induces the expression of E-cadherin in ovarian cancer cells Homo sapiens
3.5.1.98 physiological function HDAC1 enhances cell proliferation of ovarian cancer cells, the expression of HDAC1 and HDAC2 is correlated with the proliferation marker Ki-67 expression, and HDAC3 stimulates cell migration with downregulation of E-cadherin in ovarian carcinoma Homo sapiens