BRENDA - Enzyme Database

Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

Kang, M.R.; Kim, M.S.; Oh, J.E.; Kim, Y.R.; Song, S.Y.; Seo, S.I.; Lee, J.Y.; Yoo, N.J.; Lee, S.H.; Int. J. Cancer 125, 353-355 (2009)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
1.1.1.41
genotyping in diverse cancer cell lines, overview
Homo sapiens
1.1.1.42
genotyping in diverse cancer cell lines, overview
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.41
additional information
mutational analysis of IDH1 codon 132 in 1185 cancer samples, overview
Homo sapiens
1.1.1.41
R132C
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132G
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132H
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132L
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132S
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132V
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
additional information
mutational analysis of IDH1 codon 132 in 1185 cancer samples, overview
Homo sapiens
1.1.1.42
R132C
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132G
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132H
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132L
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132S
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132V
naturally occuring IDH1 mutation
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Homo sapiens
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
2-oxoglutarate + NADH + H+ + CO2
-
-
?
1.1.1.42
isocitrate + NADP+
Homo sapiens
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
2-oxoglutarate + NADPH + H+ + CO2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.41
Homo sapiens
-
-
-
1.1.1.42
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
B-cell acute lymphoblastic leukemia cell
-
Homo sapiens
-
1.1.1.41
breast carcinoma cell
-
Homo sapiens
-
1.1.1.41
colonic carcinoma cell
-
Homo sapiens
-
1.1.1.41
esophageal cancer cell
-
Homo sapiens
-
1.1.1.41
glioblastoma cell
-
Homo sapiens
-
1.1.1.41
glioma cell
-
Homo sapiens
-
1.1.1.41
hepatoma cell
-
Homo sapiens
-
1.1.1.41
kidney carcinoma cell
-
Homo sapiens
-
1.1.1.41
leukemia cell
acute
Homo sapiens
-
1.1.1.41
lung carcinoma cell
-
Homo sapiens
-
1.1.1.41
meningioma cell
malignant
Homo sapiens
-
1.1.1.41
mesothelioma cell
-
Homo sapiens
-
1.1.1.41
myeloma cell
multiple
Homo sapiens
-
1.1.1.41
ovary carcinoma cell
-
Homo sapiens
-
1.1.1.41
prostate adenocarcinoma cell
-
Homo sapiens
-
1.1.1.41
prostate carcinoma cell
-
Homo sapiens
-
1.1.1.41
skin carcinoma cell
-
Homo sapiens
-
1.1.1.41
stomach carcinoma cell
-
Homo sapiens
-
1.1.1.41
urinary bladder carcinoma cell
-
Homo sapiens
-
1.1.1.41
uterine cervix carcinoma cell
-
Homo sapiens
-
1.1.1.42
B-cell acute lymphoblastic leukemia cell
-
Homo sapiens
-
1.1.1.42
breast carcinoma cell
-
Homo sapiens
-
1.1.1.42
colonic carcinoma cell
-
Homo sapiens
-
1.1.1.42
esophageal cancer cell
-
Homo sapiens
-
1.1.1.42
glioblastoma cell
-
Homo sapiens
-
1.1.1.42
glioma cell
-
Homo sapiens
-
1.1.1.42
hepatoma cell
-
Homo sapiens
-
1.1.1.42
kidney carcinoma cell
-
Homo sapiens
-
1.1.1.42
leukemia cell
acute
Homo sapiens
-
1.1.1.42
lung carcinoma cell
-
Homo sapiens
-
1.1.1.42
meningioma cell
malignant
Homo sapiens
-
1.1.1.42
mesothelioma cell
-
Homo sapiens
-
1.1.1.42
myeloma cell
multiple
Homo sapiens
-
1.1.1.42
ovary carcinoma cell
-
Homo sapiens
-
1.1.1.42
prostate adenocarcinoma cell
-
Homo sapiens
-
1.1.1.42
prostate carcinoma cell
-
Homo sapiens
-
1.1.1.42
skin carcinoma cell
-
Homo sapiens
-
1.1.1.42
stomach carcinoma cell
-
Homo sapiens
-
1.1.1.42
urinary bladder carcinoma cell
-
Homo sapiens
-
1.1.1.42
uterine cervix carcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
712180
Homo sapiens
2-oxoglutarate + NADH + H+ + CO2
-
-
-
?
1.1.1.41
isocitrate + NAD+
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
712180
Homo sapiens
2-oxoglutarate + NADH + H+ + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
712180
Homo sapiens
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
712180
Homo sapiens
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.41
genotyping in diverse cancer cell lines, overview
Homo sapiens
1.1.1.42
genotyping in diverse cancer cell lines, overview
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.41
additional information
mutational analysis of IDH1 codon 132 in 1185 cancer samples, overview
Homo sapiens
1.1.1.41
R132C
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132G
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132H
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132L
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132S
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.41
R132V
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
additional information
mutational analysis of IDH1 codon 132 in 1185 cancer samples, overview
Homo sapiens
1.1.1.42
R132C
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132G
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132H
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132L
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132S
naturally occuring IDH1 mutation
Homo sapiens
1.1.1.42
R132V
naturally occuring IDH1 mutation
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Homo sapiens
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
2-oxoglutarate + NADH + H+ + CO2
-
-
?
1.1.1.42
isocitrate + NADP+
Homo sapiens
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
2-oxoglutarate + NADPH + H+ + CO2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
B-cell acute lymphoblastic leukemia cell
-
Homo sapiens
-
1.1.1.41
breast carcinoma cell
-
Homo sapiens
-
1.1.1.41
colonic carcinoma cell
-
Homo sapiens
-
1.1.1.41
esophageal cancer cell
-
Homo sapiens
-
1.1.1.41
glioblastoma cell
-
Homo sapiens
-
1.1.1.41
glioma cell
-
Homo sapiens
-
1.1.1.41
hepatoma cell
-
Homo sapiens
-
1.1.1.41
kidney carcinoma cell
-
Homo sapiens
-
1.1.1.41
leukemia cell
acute
Homo sapiens
-
1.1.1.41
lung carcinoma cell
-
Homo sapiens
-
1.1.1.41
meningioma cell
malignant
Homo sapiens
-
1.1.1.41
mesothelioma cell
-
Homo sapiens
-
1.1.1.41
myeloma cell
multiple
Homo sapiens
-
1.1.1.41
ovary carcinoma cell
-
Homo sapiens
-
1.1.1.41
prostate adenocarcinoma cell
-
Homo sapiens
-
1.1.1.41
prostate carcinoma cell
-
Homo sapiens
-
1.1.1.41
skin carcinoma cell
-
Homo sapiens
-
1.1.1.41
stomach carcinoma cell
-
Homo sapiens
-
1.1.1.41
urinary bladder carcinoma cell
-
Homo sapiens
-
1.1.1.41
uterine cervix carcinoma cell
-
Homo sapiens
-
1.1.1.42
B-cell acute lymphoblastic leukemia cell
-
Homo sapiens
-
1.1.1.42
breast carcinoma cell
-
Homo sapiens
-
1.1.1.42
colonic carcinoma cell
-
Homo sapiens
-
1.1.1.42
esophageal cancer cell
-
Homo sapiens
-
1.1.1.42
glioblastoma cell
-
Homo sapiens
-
1.1.1.42
glioma cell
-
Homo sapiens
-
1.1.1.42
hepatoma cell
-
Homo sapiens
-
1.1.1.42
kidney carcinoma cell
-
Homo sapiens
-
1.1.1.42
leukemia cell
acute
Homo sapiens
-
1.1.1.42
lung carcinoma cell
-
Homo sapiens
-
1.1.1.42
meningioma cell
malignant
Homo sapiens
-
1.1.1.42
mesothelioma cell
-
Homo sapiens
-
1.1.1.42
myeloma cell
multiple
Homo sapiens
-
1.1.1.42
ovary carcinoma cell
-
Homo sapiens
-
1.1.1.42
prostate adenocarcinoma cell
-
Homo sapiens
-
1.1.1.42
prostate carcinoma cell
-
Homo sapiens
-
1.1.1.42
skin carcinoma cell
-
Homo sapiens
-
1.1.1.42
stomach carcinoma cell
-
Homo sapiens
-
1.1.1.42
urinary bladder carcinoma cell
-
Homo sapiens
-
1.1.1.42
uterine cervix carcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
712180
Homo sapiens
2-oxoglutarate + NADH + H+ + CO2
-
-
-
?
1.1.1.41
isocitrate + NAD+
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
712180
Homo sapiens
2-oxoglutarate + NADH + H+ + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
712180
Homo sapiens
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
712180
Homo sapiens
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?