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Literature summary extracted from

  • Matteoli, G.; Mazzini, E.; Iliev, I.D.; Mileti, E.; Fallarino, F.; Puccetti, P.; Chieppa, M.; Rescigno, M.
    Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction (2010), Gut, 59, 595-604.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-methyl-D-tryptophan the isomer is more effective in inhibiting IDO than 1-methyl-L-tryptophan Homo sapiens
1.13.11.52 1-methyl-D-tryptophan the isomer is more effective in inhibiting IDO than 1-methyl-L-tryptophan Mus musculus
1.13.11.52 1-methyl-DL-tryptophan
-
 Homo sapiens
1.13.11.52 1-methyl-DL-tryptophan
-
 Mus musculus
1.13.11.52 1-methyl-L-tryptophan the isomer is less effective in inhibiting IDO than 1-methyl-D-tryptophan Homo sapiens
1.13.11.52 1-methyl-L-tryptophan the isomer is less effective in inhibiting IDO than 1-methyl-D-tryptophan Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-tryptophan + O2 Mus musculus
-
 N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens
-
-
-
1.13.11.52 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 colon
-
 Mus musculus
-
1.13.11.52 colon
-
 Homo sapiens
-
1.13.11.52 culture condition:CD103+ cell
-
 Mus musculus
-
1.13.11.52 culture condition:CD103+ cell
-
 Homo sapiens
-
1.13.11.52 duodenum
-
 Mus musculus
-
1.13.11.52 duodenum
-
 Homo sapiens
-
1.13.11.52 ileum IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level Mus musculus
-
1.13.11.52 ileum IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level Homo sapiens
-
1.13.11.52 intestine IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level Mus musculus
-
1.13.11.52 intestine IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level Homo sapiens
-
1.13.11.52 jejunum IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level Mus musculus
-
1.13.11.52 jejunum IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level Homo sapiens
-
1.13.11.52 additional information IDO is not detected in CD103- gut dendritic cells and in spleen Mus musculus
-
1.13.11.52 additional information IDO is not detected in CD103- gut dendritic cells and in spleen Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-tryptophan + O2
-
 Mus musculus N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO
-
 Mus musculus
1.13.11.52 IDO
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Mus musculus
1.13.11.52 heme
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.52 malfunction IDO inhibition significantly affects the ability of CD103+ dendritic cells to promote conversion of naive T cells into Foxp3+Tregs while the ability of CD103- cells is unaffected. IDO inhibition impinges on the development of oral tolerance Mus musculus
1.13.11.52 malfunction IDO inhibition significantly affects the ability of CD103+ denxritic cells to promote conversion of naive T cells into Foxp3+Tregs while the ability of CD103- cells is unaffected. IDO inhibition impinges on the development of oral tolerance Homo sapiens
1.13.11.52 physiological function indoleamine 2,3-dioxygenase is an enzyme involved in tryptophan catabolism with immunosuppressive effects influencing T regulatory/T effector cell balance and oral tolerance induction Mus musculus
1.13.11.52 physiological function indoleamine 2,3-dioxygenase is an enzyme involved in tryptophan catabolism with immunosuppressive effects influencing T regulatory/T effector cell balance and oral tolerance induction Homo sapiens