Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ramos, L.; Chavez, B.; Vilchis, F.
    Cloning and differential expression of steroid 5alpha-reductase type 1 (Srd5a1) and type 2 (Srd5a2) from the Harderian glands of hamsters (2010), Gen. Comp. Endocrinol., 166, 388-395.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.99.5 Srd5a1 DNA and amino acid sequence determination and analysis, expression of Srd5a2 in HEK-293 cells, real-time quantitative RT-PCR expression analysis with higher mRNA levels for Srd5a1 than for Srd5a2 Mesocricetus auratus
1.3.99.5 Srd5a2 DNA and amino acid sequence determination and analysis, expression of Srd5a2 in HEK-293 cells, real-time quantitative RT-PCR expression analysis with higher mRNA levels for Srd5a1 than for Srd5a2 Mesocricetus auratus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.99.5 0.0019
-
testosterone Srd5a2, pH not specified in the publication, temperature not specified in the publication Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.99.5 dihydrotestosterone + NADP+ Mesocricetus auratus the isoenzyme efficiently catalyzes the in vitro transformation of testosterone into dihydrotestosterone testosterone + NADPH + H+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.3.99.5 Mesocricetus auratus C7T2J7 Srd5a1
-
1.3.99.5 Mesocricetus auratus C7T2J8 Srd5a2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.99.5 epididymis Srd5a2 Mesocricetus auratus
-
1.3.99.5 harderian gland both Srd5a1 and Srd5a2 are expressed without clear differences between males and females Mesocricetus auratus
-
1.3.99.5 liver Srd5a1 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.99.5 dihydrotestosterone + NADP+
-
Mesocricetus auratus testosterone + NADPH + H+
-
r
1.3.99.5 dihydrotestosterone + NADP+ the isoenzyme efficiently catalyzes the in vitro transformation of testosterone into dihydrotestosterone Mesocricetus auratus testosterone + NADPH + H+
-
r

Synonyms

EC Number Synonyms Comment Organism
1.3.99.5 SRD5A1
-
Mesocricetus auratus
1.3.99.5 SRD5A2
-
Mesocricetus auratus
1.3.99.5 steroid 5alpha-reductase type 1
-
Mesocricetus auratus
1.3.99.5 steroid 5alpha-reductase type 2
-
Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.99.5 5.5
-
recombinant Srd5a2 Mesocricetus auratus
1.3.99.5 6.5 8 recombinant Srd5a1 Mesocricetus auratus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.99.5 NADP+
-
Mesocricetus auratus
1.3.99.5 NADPH
-
Mesocricetus auratus

Expression

EC Number Organism Comment Expression
1.3.99.5 Mesocricetus auratus 17beta-estradiol administered to spayed females induces the up-regulation of Srd5a2 mRNA levels up

General Information

EC Number General Information Comment Organism
1.3.99.5 physiological function the isozyme may play a relevant role in modulating androgen signaling in Hardarian glands Mesocricetus auratus