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Literature summary extracted from

  • Kim, S.Y.; Kim, J.
    Roles of dihydrolipoamide dehydrogenase Lpd1 in Candida albicans filamentation (2010), Fungal Genet. Biol., 47, 782-788.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.4 mitochondrion Lpd1 protein is localized in the mitochondria during the logarithmic yeast growth and the filamentous growth Candida albicans 5739
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Organism

EC Number Organism UniProt Comment Textmining
1.8.1.4 Candida albicans
-
-
-
1.8.1.4 Candida albicans CAI-4
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.4 dihydrolipoamide + NAD+
-
 Candida albicans lipoamide + NADH
-
 ?
1.8.1.4 dihydrolipoamide + NAD+
-
 Candida albicans CAI-4 lipoamide + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.4 LPD1
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 Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.4 FAD
-
 Candida albicans
1.8.1.4 NAD+
-
 Candida albicans

General Information

EC Number General Information Comment Organism
1.8.1.4 malfunction the homozygous deletion mutant lpd1/lpd1 is unable to grow on non-fermentable carbon sources including glycerol, ethanol, acetate, and citrate. In addition, the lpd1/lpd1 strain exhibits a slow-growth phenotype on glucose-containing media and a marked sensitivity to 0.5 mM of hydrogen peroxide and shows filamentation defects Candida albicans
1.8.1.4 physiological function dihydrolipoamide dehydrogenase Lpd1 is a catalytic component of pyruvate dehydrogenase complex. LPD1 is required for filamentous growth under a serum-containing hyphal-inducing condition Candida albicans