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Literature summary extracted from

  • Prast-Nielsen, S.; Cebula, M.; Pader, I.; Arner, E.S.
    Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin (2010), Free Radic. Biol. Med., 49, 1765-1778.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 auranofin about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 80% residual activity at 400 nM for juglone reduction Homo sapiens
1.8.1.9 auranofin about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 80% residual activity at 400 nM for juglone reduction Rattus norvegicus
1.8.1.9 cisplatin i.e. cis-diamminedichloroplatinum(II), about 3% residual activity at 400 nM in the presence of NADPH, about 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction Homo sapiens
1.8.1.9 cisplatin i.e. cis-diamminedichloroplatinum(II), about 3% residual activity at 400 nM in the presence of NADPH, about 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction Rattus norvegicus
1.8.1.9 gold potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Homo sapiens
1.8.1.9 gold potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Rattus norvegicus
1.8.1.9 K2PdCl4 strong and irreversible inhibition, about 30% residual activity at 400 nM in the presence of NADPH, less than 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction Homo sapiens
1.8.1.9 K2PdCl4 strong and irreversible inhibition, about 30% residual activity at 400 nM in the presence of NADPH, less than 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction Rattus norvegicus
1.8.1.9 K2PdCl6 irreversible inhibition Homo sapiens
1.8.1.9 K2PdCl6 irreversible inhibition Rattus norvegicus
1.8.1.9 K2PtCl4 irreversible inhibition, about 5% residual activity at 400 nM in the presence of NADPH, complete inhibition of 5,5'-dithiobis(2-nitrobenzoic acid) reduction at 400 nM, about 90% residual activity at 400 nM for juglone reduction Homo sapiens
1.8.1.9 K2PtCl4 irreversible inhibition, about 5% residual activity at 400 nM in the presence of NADPH, complete inhibition of 5,5'-dithiobis(2-nitrobenzoic acid) reduction at 400 nM, about 90% residual activity at 400 nM for juglone reduction Rattus norvegicus
1.8.1.9 K2PtCl6 irreversible inhibition Homo sapiens
1.8.1.9 K2PtCl6 irreversible inhibition Rattus norvegicus
1.8.1.9 KAuCl4 irreversible inhibition, about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 70% residual activity at 400 nM for juglone reduction Homo sapiens
1.8.1.9 KAuCl4 irreversible inhibition, about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 70% residual activity at 400 nM for juglone reduction Rattus norvegicus
1.8.1.9 palladium potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Homo sapiens
1.8.1.9 palladium potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Rattus norvegicus
1.8.1.9 platinum the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Homo sapiens
1.8.1.9 platinum the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.9 65000
-
 SDS-PAGE Homo sapiens
1.8.1.9 65000
-
 SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Homo sapiens
-
-
-
1.8.1.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 A-549 cell
-
 Homo sapiens
-
1.8.1.9 HeLa cell
-
 Homo sapiens
-
1.8.1.9 NCI-H23 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
 Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
 Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 juglone + NADPH + H+
-
 Homo sapiens ?
-
 ?
1.8.1.9 juglone + NADPH + H+
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
 Homo sapiens
1.8.1.9 thioredoxin reductase
-
 Rattus norvegicus
1.8.1.9 TrxR1
-
 Homo sapiens
1.8.1.9 TrxR1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
 Homo sapiens
1.8.1.9 FAD
-
 Rattus norvegicus
1.8.1.9 NADPH
-
 Homo sapiens
1.8.1.9 NADPH
-
 Rattus norvegicus