Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sliskovic, I.; Abdulhamid, I.; Sharma, M.; Abu-Soud, H.M.
    Analysis of the mechanism by which tryptophan analogs inhibit human myeloperoxidase (2009), Free Radic. Biol. Med., 47, 1005-1013.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.7 1-methyl-L-tryptophan
-
 Homo sapiens
1.11.1.7 5-fluoro-L-tryptophan
-
 Homo sapiens
1.11.1.7 L-tryptophan
-
 Homo sapiens
1.11.1.7 L-tryptophan benzyl ester
-
 Homo sapiens
1.11.1.7 Nalpha-methoxycarbonyl-L-tryptophan methyl ester
-
 Homo sapiens
1.11.1.7 Nalpha-methyl-L-tryptophan
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.7 leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.7 Cl- + H2O2
-
 Homo sapiens HOCl + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.7 MPO
-
 Homo sapiens
1.11.1.7 myeloperoxidase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.11.1.7 0.000175
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens L-tryptophan benzyl ester
1.11.1.7 0.00035
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens Nalpha-methoxycarbonyl-L-tryptophan methyl ester
1.11.1.7 0.00175
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens 1-methyl-L-tryptophan
1.11.1.7 0.00225
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens L-tryptophan
1.11.1.7 0.00325
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens 5-fluoro-L-tryptophan
1.11.1.7 0.0052
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens Nalpha-methyl-L-tryptophan