BRENDA - Enzyme Database show

Lauroylethanolamide is a potent competitive inhibitor of lipoxygenase activity

Keereetaweep, J.; Kilaru, A.; Feussner, I.; Venables, B.J.; Chapman, K.D.; FEBS Lett. 584, 3215-3222 (2010)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.13.11.12
lauric acid
-
Glycine max
1.13.11.12
lauroylethanolamide
-
Glycine max
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.13.11.12
0.015
-
N-linolenoylethanolamide
in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.021
-
linoleate
in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.027
-
N-linoleoylethanolamide
in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.032
-
alpha-linolenate
in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.13.11.12
Glycine max
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.13.11.12
alpha-linolenate + O2
-
712022
Glycine max
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
-
-
-
?
1.13.11.12
linoleate + O2
-
712022
Glycine max
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
?
1.13.11.12
N-linolenoylethanolamide + O2
-
712022
Glycine max
?
-
-
-
?
1.13.11.12
N-linoleoylethanolamide + O2
-
712022
Glycine max
?
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.13.11.12
0.0005
-
lauroylethanolamide
using linoleate as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0006
-
lauroylethanolamide
using N-linoleoylethanolamide as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0007
-
lauroylethanolamide
using N-linolenoylethanolamide as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0009
-
lauroylethanolamide
using alpha-linolenate as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0084
-
lauric acid
using N-linoleoylethanolamide as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0121
-
lauric acid
using linoleate as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0146
-
lauric acid
using N-linolenoylethanolamide as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.015
-
lauric acid
using alpha-linolenate as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.13.11.12
lauric acid
-
Glycine max
1.13.11.12
lauroylethanolamide
-
Glycine max
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.13.11.12
0.0005
-
lauroylethanolamide
using linoleate as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0006
-
lauroylethanolamide
using N-linoleoylethanolamide as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0007
-
lauroylethanolamide
using N-linolenoylethanolamide as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0009
-
lauroylethanolamide
using alpha-linolenate as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0084
-
lauric acid
using N-linoleoylethanolamide as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0121
-
lauric acid
using linoleate as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.0146
-
lauric acid
using N-linolenoylethanolamide as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.015
-
lauric acid
using alpha-linolenate as substrate, in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.13.11.12
0.015
-
N-linolenoylethanolamide
in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.021
-
linoleate
in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.027
-
N-linoleoylethanolamide
in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
1.13.11.12
0.032
-
alpha-linolenate
in 0.1 M borate (pH 9.0), temperature not specified in the publication
Glycine max
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.13.11.12
alpha-linolenate + O2
-
712022
Glycine max
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
-
-
-
?
1.13.11.12
linoleate + O2
-
712022
Glycine max
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
?
1.13.11.12
N-linolenoylethanolamide + O2
-
712022
Glycine max
?
-
-
-
?
1.13.11.12
N-linoleoylethanolamide + O2
-
712022
Glycine max
?
-
-
-
?