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Literature summary extracted from

  • Duschene, K.S.; Broderick, J.B.
    The antiviral protein viperin is a radical SAM enzyme (2010), FEBS Lett., 584, 1263-1267.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.98.3 gene cig5, expression of viperin lacking the leucine zipper domain, viperin43-340, in Escherichia coli Rosetta(DE3)pLysS cells Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.98.3 Fe2+ [4Fe-4S]1+ cluster and [3Fe-4S]1+ cluster Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.98.3 coproporphyrinogen III + 2 S-adenosyl-L-methionine Homo sapiens
-
 protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.98.3 Homo sapiens
-
 gene cig5
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.98.3 coproporphyrinogen III + 2 S-adenosyl-L-methionine
-
 Homo sapiens protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine
-
 ?
1.3.98.3 coproporphyrinogen III + 2 S-adenosyl-L-methionine reductive cleavage of S-adenosyl-L-methionine to produce methionine and a 5'-deoxyadenosyl radical intermediate, a reaction characteristic of the radical SAM superfamily, due to the presence of a CX3CX2C motif Homo sapiens protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine detection of the cleavage and degradation products and analysis by mass spectrometry, overview ?

Synonyms

EC Number Synonyms Comment Organism
1.3.98.3 viperin
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.98.3 7
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.98.3 [3Fe-4S]1+ cluster
-
 Homo sapiens
1.3.98.3 [4Fe-4S]1+ cluster
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.3.98.3 additional information the interferon-inducible antiviral protein viperin is a radical SAM enzyme, immune response pathway involving viperin that leads to the disruption of viral release from the plasma membrane, overview Homo sapiens