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Literature summary extracted from

  • Ding, B.; Gibbs, P.E.; Brookes, P.S.; Maines, M.D.
    The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction (2010), FASEB J., 25, 301-313.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.3.1.24 medicine finding that BVR and HO-2 levels, myocyte apoptosis, and contractile function of the heart can be modulated by small human BVR-based peptides offers a promising therapeutic approach for treatment of cardiac dysfunctions Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.24 expression in HEK-293A cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.24 additional information inhibition of isoproterenol-induced expression of BVR using siBVR Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 bilirubin + NAD+ Homo sapiens
-
 biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NAD+ Rattus norvegicus
-
 biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NADP+ Homo sapiens
-
 biliverdin + NADPH + H+
-
 r
1.3.1.24 bilirubin + NADP+ Rattus norvegicus
-
 biliverdin + NADPH + H+
-
 r
1.3.1.24 additional information Homo sapiens BVR is an S/T/Y kinase ?
-
 ?
1.3.1.24 additional information Rattus norvegicus BVR is an S/T/Y kinase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens
-
-
-
1.3.1.24 Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 cardiomyocyte
-
 Rattus norvegicus
-
1.3.1.24 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 bilirubin + NAD+
-
 Homo sapiens biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NAD+
-
 Rattus norvegicus biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 r
1.3.1.24 bilirubin + NADP+
-
 Rattus norvegicus biliverdin + NADPH + H+
-
 r
1.3.1.24 additional information BVR is an S/T/Y kinase Homo sapiens ?
-
 ?
1.3.1.24 additional information BVR is an S/T/Y kinase Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 BVR
-
 Homo sapiens
1.3.1.24 BVR
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.24 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.24 6.7
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NAD+
-
 Homo sapiens
1.3.1.24 NAD+
-
 Rattus norvegicus
1.3.1.24 NADH
-
 Homo sapiens
1.3.1.24 NADH
-
 Rattus norvegicus
1.3.1.24 NADP+
-
 Homo sapiens
1.3.1.24 NADP+
-
 Rattus norvegicus
1.3.1.24 NADPH
-
 Homo sapiens
1.3.1.24 NADPH
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.3.1.24 Rattus norvegicus induction of BVR and HO-2 is mediated by the cAMP-PKA pathway and isoproterenol, overview up
1.3.1.24 Homo sapiens induction of BVR and HO-2 is mediated by the cAMP-PKA pathway and isoproterenol, overview. The beta-adrenergic antagonist propranolol only slightly induces BVR expression in HEK-293A cells up

General Information

EC Number General Information Comment Organism
1.3.1.24 additional information isoproterenol, ISO, stimulation of BVR levels enhances the stability of heme oxygenase 2, HO-2. Interaction between HO-2 and BVR is a survival factor for cardiomyocytes during ISO stimulation Homo sapiens
1.3.1.24 physiological function blockage of BVR protein expression by retroviral siBVR inhibits the HO-2 protein induction but not vice versa Rattus norvegicus
1.3.1.24 physiological function coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival, a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction Homo sapiens