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Literature summary extracted from

  • Johnson, A.R.; Craciunescu, C.N.; Guo, Z.; Teng, Y.W.; Thresher, R.J.; Blusztajn, J.K.; Zeisel, S.H.
    Deletion of murine choline dehydrogenase results in diminished sperm motility (2010), FASEB J., 24, 2752-2761.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.99.1 mitochondrial membrane
-
 Mus musculus 31966
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.99.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.99.1 heart
-
 Mus musculus
-
1.1.99.1 kidney highest activity Mus musculus
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1.1.99.1 liver highest activity Mus musculus
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1.1.99.1 additional information almost no activity is detected in brain and skeletal muscle Mus musculus
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1.1.99.1 testis highest activity Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.99.1 choline + acceptor
-
 Mus musculus betaine aldehyde + reduced acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.99.1 CHDH
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.1.99.1 Mus musculus liver samples from Chdh-deficient mice have 37% of the CHDH activity measured in wild type samples down

General Information

EC Number General Information Comment Organism
1.1.99.1 malfunction deletion of choline dehydrogenase results in diminished sperm motility with abnormal mitochondrial morphology, but does not affect fetal viability or alter growth or liver, kidney, or muscle function. Loss of choline dehydrogenase activity results in decreased testicular betaine and increased choline and phosphocholine concentrations. Mitochondrial changes are also detected in liver, kidney, heart, and testis tissues. Chdh-deficient mice have increased plasma total homocysteine Mus musculus