Literature summary extracted from

Sharma, A.; Khuller, G.K.; Sharma, S.
Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery (2009), Expert Opin. Ther. Targets, 13, 753-765.

Application

EC Number	Application	Comment	Organism
3.5.1.88	medicine	peptide deformylase is a therapeutic target for tuberculosis	Homo sapiens
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Escherichia coli
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Streptococcus pneumoniae
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Staphylococcus aureus
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Staphylococcus epidermidis
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Enterococcus sp.
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Bacillus subtilis
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Moraxella catarrhalis
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Neisseria gonorrhoeae
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Stenotrophomonas maltophilia
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Bacteroides fragilis
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Klebsiella pneumoniae
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Enterobacter cloacae
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Pseudomonas aeruginosa
3.5.1.88	medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Mycobacterium tuberculosis variant bovis
3.5.1.88	medicine	peptide deformylase is a therapeutic target for tuberculosis	Mycobacterium tuberculosis

Inhibitors

EC Number	Inhibitors	Comment	Organism
3.5.1.88	(2R)-N-[(3S)-2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4,4-dimethylpent-1-en-3-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide	-	Homo sapiens
3.5.1.88	(2R)-N-[(3S)-2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4,4-dimethylpent-1-en-3-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide	-	Mycobacterium tuberculosis
3.5.1.88	actinonin	-	Bacillus subtilis
3.5.1.88	actinonin	-	Bacteroides fragilis
3.5.1.88	actinonin	-	Enterobacter cloacae
3.5.1.88	actinonin	-	Enterococcus sp.
3.5.1.88	actinonin	-	Escherichia coli
3.5.1.88	actinonin	-	Homo sapiens
3.5.1.88	actinonin	-	Klebsiella pneumoniae
3.5.1.88	actinonin	-	Moraxella catarrhalis
3.5.1.88	actinonin	-	Mycobacterium tuberculosis
3.5.1.88	actinonin	-	Mycobacterium tuberculosis variant bovis
3.5.1.88	actinonin	-	Neisseria gonorrhoeae
3.5.1.88	actinonin	-	Plasmodium falciparum
3.5.1.88	actinonin	-	Pseudomonas aeruginosa
3.5.1.88	actinonin	-	Staphylococcus aureus
3.5.1.88	actinonin	-	Staphylococcus epidermidis
3.5.1.88	actinonin	-	Stenotrophomonas maltophilia
3.5.1.88	actinonin	-	Streptococcus pneumoniae
3.5.1.88	BB-3497	-	Bacillus subtilis
3.5.1.88	BB-3497	-	Bacteroides fragilis
3.5.1.88	BB-3497	-	Enterobacter cloacae
3.5.1.88	BB-3497	-	Enterococcus sp.
3.5.1.88	BB-3497	-	Escherichia coli
3.5.1.88	BB-3497	-	Homo sapiens
3.5.1.88	BB-3497	-	Klebsiella pneumoniae
3.5.1.88	BB-3497	-	Moraxella catarrhalis
3.5.1.88	BB-3497	-	Mycobacterium tuberculosis
3.5.1.88	BB-3497	-	Mycobacterium tuberculosis variant bovis
3.5.1.88	BB-3497	-	Neisseria gonorrhoeae
3.5.1.88	BB-3497	-	Plasmodium falciparum
3.5.1.88	BB-3497	-	Pseudomonas aeruginosa
3.5.1.88	BB-3497	-	Staphylococcus aureus
3.5.1.88	BB-3497	-	Staphylococcus epidermidis
3.5.1.88	BB-3497	-	Stenotrophomonas maltophilia
3.5.1.88	BB-3497	-	Streptococcus pneumoniae
3.5.1.88	BB-81384	-	Bacillus subtilis
3.5.1.88	BB-81384	-	Bacteroides fragilis
3.5.1.88	BB-81384	-	Enterobacter cloacae
3.5.1.88	BB-81384	-	Enterococcus sp.
3.5.1.88	BB-81384	-	Escherichia coli
3.5.1.88	BB-81384	-	Homo sapiens
3.5.1.88	BB-81384	-	Klebsiella pneumoniae
3.5.1.88	BB-81384	-	Moraxella catarrhalis
3.5.1.88	BB-81384	-	Mycobacterium tuberculosis
3.5.1.88	BB-81384	-	Mycobacterium tuberculosis variant bovis
3.5.1.88	BB-81384	-	Neisseria gonorrhoeae
3.5.1.88	BB-81384	-	Plasmodium falciparum
3.5.1.88	BB-81384	-	Pseudomonas aeruginosa
3.5.1.88	BB-81384	-	Staphylococcus aureus
3.5.1.88	BB-81384	-	Staphylococcus epidermidis
3.5.1.88	BB-81384	-	Stenotrophomonas maltophilia
3.5.1.88	BB-81384	-	Streptococcus pneumoniae
3.5.1.88	BB-83698	-	Bacillus subtilis
3.5.1.88	BB-83698	-	Bacteroides fragilis
3.5.1.88	BB-83698	-	Enterobacter cloacae
3.5.1.88	BB-83698	-	Enterococcus sp.
3.5.1.88	BB-83698	-	Escherichia coli
3.5.1.88	BB-83698	-	Homo sapiens
3.5.1.88	BB-83698	-	Klebsiella pneumoniae
3.5.1.88	BB-83698	-	Moraxella catarrhalis
3.5.1.88	BB-83698	-	Mycobacterium tuberculosis
3.5.1.88	BB-83698	-	Mycobacterium tuberculosis variant bovis
3.5.1.88	BB-83698	-	Neisseria gonorrhoeae
3.5.1.88	BB-83698	-	Plasmodium falciparum
3.5.1.88	BB-83698	-	Pseudomonas aeruginosa
3.5.1.88	BB-83698	-	Staphylococcus aureus
3.5.1.88	BB-83698	-	Staphylococcus epidermidis
3.5.1.88	BB-83698	-	Stenotrophomonas maltophilia
3.5.1.88	BB-83698	-	Streptococcus pneumoniae
3.5.1.88	tert-butyl 1-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]hexanoyl]-L-prolinate	-	Homo sapiens
3.5.1.88	tert-butyl 1-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]hexanoyl]-L-prolinate	-	Mycobacterium tuberculosis
3.5.1.88	VIC-104959	LBM415	Bacillus subtilis
3.5.1.88	VIC-104959	LBM415	Bacteroides fragilis
3.5.1.88	VIC-104959	LBM415	Enterobacter cloacae
3.5.1.88	VIC-104959	LBM415	Enterococcus sp.
3.5.1.88	VIC-104959	LBM415	Escherichia coli
3.5.1.88	VIC-104959	LBM415	Homo sapiens
3.5.1.88	VIC-104959	LBM415	Klebsiella pneumoniae
3.5.1.88	VIC-104959	LBM415	Moraxella catarrhalis
3.5.1.88	VIC-104959	LBM415	Mycobacterium tuberculosis
3.5.1.88	VIC-104959	LBM415	Mycobacterium tuberculosis variant bovis
3.5.1.88	VIC-104959	LBM415	Neisseria gonorrhoeae
3.5.1.88	VIC-104959	LBM415	Plasmodium falciparum
3.5.1.88	VIC-104959	LBM415	Pseudomonas aeruginosa
3.5.1.88	VIC-104959	LBM415	Staphylococcus aureus
3.5.1.88	VIC-104959	LBM415	Staphylococcus epidermidis
3.5.1.88	VIC-104959	LBM415	Stenotrophomonas maltophilia
3.5.1.88	VIC-104959	LBM415	Streptococcus pneumoniae
3.5.1.88	VRC-3375	-	Bacillus subtilis
3.5.1.88	VRC-3375	-	Bacteroides fragilis
3.5.1.88	VRC-3375	-	Enterobacter cloacae
3.5.1.88	VRC-3375	-	Enterococcus sp.
3.5.1.88	VRC-3375	-	Escherichia coli
3.5.1.88	VRC-3375	-	Homo sapiens
3.5.1.88	VRC-3375	-	Klebsiella pneumoniae
3.5.1.88	VRC-3375	-	Moraxella catarrhalis
3.5.1.88	VRC-3375	-	Mycobacterium tuberculosis
3.5.1.88	VRC-3375	-	Mycobacterium tuberculosis variant bovis
3.5.1.88	VRC-3375	-	Neisseria gonorrhoeae
3.5.1.88	VRC-3375	-	Plasmodium falciparum
3.5.1.88	VRC-3375	-	Pseudomonas aeruginosa
3.5.1.88	VRC-3375	-	Staphylococcus aureus
3.5.1.88	VRC-3375	-	Staphylococcus epidermidis
3.5.1.88	VRC-3375	-	Stenotrophomonas maltophilia
3.5.1.88	VRC-3375	-	Streptococcus pneumoniae
3.5.1.88	VRC-4307	-	Bacillus subtilis
3.5.1.88	VRC-4307	-	Bacteroides fragilis
3.5.1.88	VRC-4307	-	Enterobacter cloacae
3.5.1.88	VRC-4307	-	Enterococcus sp.
3.5.1.88	VRC-4307	-	Escherichia coli
3.5.1.88	VRC-4307	-	Homo sapiens
3.5.1.88	VRC-4307	-	Klebsiella pneumoniae
3.5.1.88	VRC-4307	-	Moraxella catarrhalis
3.5.1.88	VRC-4307	-	Mycobacterium tuberculosis
3.5.1.88	VRC-4307	-	Mycobacterium tuberculosis variant bovis
3.5.1.88	VRC-4307	-	Neisseria gonorrhoeae
3.5.1.88	VRC-4307	-	Plasmodium falciparum
3.5.1.88	VRC-4307	-	Pseudomonas aeruginosa
3.5.1.88	VRC-4307	-	Staphylococcus aureus
3.5.1.88	VRC-4307	-	Staphylococcus epidermidis
3.5.1.88	VRC-4307	-	Stenotrophomonas maltophilia
3.5.1.88	VRC-4307	-	Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Homo sapiens	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Escherichia coli	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Plasmodium falciparum	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Streptococcus pneumoniae	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Staphylococcus aureus	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Staphylococcus epidermidis	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Enterococcus sp.	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Bacillus subtilis	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Moraxella catarrhalis	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Neisseria gonorrhoeae	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Stenotrophomonas maltophilia	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Bacteroides fragilis	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Klebsiella pneumoniae	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Enterobacter cloacae	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Pseudomonas aeruginosa	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Mycobacterium tuberculosis variant bovis	-	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	Mycobacterium tuberculosis	-	formate + L-methionine-polypeptide	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.1.88	Bacillus subtilis	-	-	-
3.5.1.88	Bacteroides fragilis	-	-	-
3.5.1.88	Enterobacter cloacae	-	-	-
3.5.1.88	Enterococcus sp.	-	-	-
3.5.1.88	Escherichia coli	-	-	-
3.5.1.88	Homo sapiens	-	-	-
3.5.1.88	Klebsiella pneumoniae	-	-	-
3.5.1.88	Moraxella catarrhalis	-	-	-
3.5.1.88	Mycobacterium tuberculosis	-	-	-
3.5.1.88	Mycobacterium tuberculosis variant bovis	-	-	-
3.5.1.88	Neisseria gonorrhoeae	-	-	-
3.5.1.88	Plasmodium falciparum	-	-	-
3.5.1.88	Pseudomonas aeruginosa	-	-	-
3.5.1.88	Staphylococcus aureus	-	-	-
3.5.1.88	Staphylococcus epidermidis	-	-	-
3.5.1.88	Stenotrophomonas maltophilia	-	-	-
3.5.1.88	Streptococcus pneumoniae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Homo sapiens	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Escherichia coli	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Plasmodium falciparum	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Streptococcus pneumoniae	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Staphylococcus aureus	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Staphylococcus epidermidis	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Enterococcus sp.	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Bacillus subtilis	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Moraxella catarrhalis	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Neisseria gonorrhoeae	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Stenotrophomonas maltophilia	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Bacteroides fragilis	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Klebsiella pneumoniae	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Enterobacter cloacae	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Pseudomonas aeruginosa	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Mycobacterium tuberculosis variant bovis	formate + L-methionine-polypeptide	-	?
3.5.1.88	N-formyl-L-methionine-polypeptide + H2O	-	Mycobacterium tuberculosis	formate + L-methionine-polypeptide	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.1.88	PDF	-	Homo sapiens
3.5.1.88	PDF	-	Escherichia coli
3.5.1.88	PDF	-	Plasmodium falciparum
3.5.1.88	PDF	-	Streptococcus pneumoniae
3.5.1.88	PDF	-	Staphylococcus aureus
3.5.1.88	PDF	-	Staphylococcus epidermidis
3.5.1.88	PDF	-	Enterococcus sp.
3.5.1.88	PDF	-	Bacillus subtilis
3.5.1.88	PDF	-	Moraxella catarrhalis
3.5.1.88	PDF	-	Neisseria gonorrhoeae
3.5.1.88	PDF	-	Stenotrophomonas maltophilia
3.5.1.88	PDF	-	Bacteroides fragilis
3.5.1.88	PDF	-	Klebsiella pneumoniae
3.5.1.88	PDF	-	Enterobacter cloacae
3.5.1.88	PDF	-	Pseudomonas aeruginosa
3.5.1.88	PDF	-	Mycobacterium tuberculosis variant bovis
3.5.1.88	PDF	-	Mycobacterium tuberculosis

General Information

EC Number	General Information	Comment	Organism
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Homo sapiens
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Escherichia coli
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Plasmodium falciparum
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Streptococcus pneumoniae
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Staphylococcus aureus
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Staphylococcus epidermidis
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Enterococcus sp.
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Bacillus subtilis
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Moraxella catarrhalis
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Neisseria gonorrhoeae
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Stenotrophomonas maltophilia
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Bacteroides fragilis
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Klebsiella pneumoniae
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Enterobacter cloacae
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Pseudomonas aeruginosa
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Mycobacterium tuberculosis variant bovis
3.5.1.88	physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Mycobacterium tuberculosis