EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | 1-Methyltryptophan | - |
Homo sapiens | |
1.13.11.52 | 2,2-dimethyl-1a,9b-dihydro-2H-benzo[g]oxireno[c]chromene-4,9-dione | - |
Homo sapiens | |
1.13.11.52 | 2-methylnaphthalene-1,4-dione | - |
Homo sapiens | |
1.13.11.52 | 3-(1H-imidazol-4-yl)benzaldehyde | - |
Homo sapiens | |
1.13.11.52 | 3-hydroxy-2,2-dimethyl-4-(morpholin-4-yl)-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | - |
Homo sapiens | |
1.13.11.52 | 3-hydroxy-4-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione | - |
Homo sapiens | |
1.13.11.52 | 4-(2-fluorophenyl)-1H-imidazole | - |
Homo sapiens | |
1.13.11.52 | 4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | - |
Homo sapiens | |
1.13.11.52 | 4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | - |
Homo sapiens | |
1.13.11.52 | 4-(thiophen-2-yl)-1H-imidazole | - |
Homo sapiens | |
1.13.11.52 | 4-fluoro-2-(1H-pyrazol-3-yl)phenol | - |
Homo sapiens | |
1.13.11.52 | 4-phenylimidazole | weak noncompetitive inhibitor of IDO | Homo sapiens | |
1.13.11.52 | 4-[2-(methylsulfanyl)phenyl]-1H-imidazole | - |
Homo sapiens | |
1.13.11.52 | 4-[3-(methylsulfanyl)phenyl]-1H-imidazole | - |
Homo sapiens | |
1.13.11.52 | 6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | - |
Homo sapiens | |
1.13.11.52 | 8-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione | - |
Homo sapiens | |
1.13.11.52 | 9-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione | - |
Homo sapiens | |
1.13.11.52 | gamma-glutamyl-S-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)cysteinylglycine | - |
Homo sapiens | |
1.13.11.52 | naphthalene-1,4-dione | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.52 | L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.52 | Homo sapiens | P14902 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.52 | L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.52 | IDO | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | heme | IDO is active when the heme iron is in the ferrous (Fe2+) form and inactive when it is in ferric (Fe3+) form | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.13.11.52 | 0.000055 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | |
1.13.11.52 | 0.00013 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | |
1.13.11.52 | 0.00019 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | |
1.13.11.52 | 0.00025 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | |
1.13.11.52 | 0.00036 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-hydroxy-2,2-dimethyl-4-(morpholin-4-yl)-3,4-dihydro-2H-benzo[g]chromene-5,10-dione | |
1.13.11.52 | 0.00088 | - |
pH and temperature not specified in the publication | Homo sapiens | gamma-glutamyl-S-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)cysteinylglycine | |
1.13.11.52 | 0.00099 | - |
pH and temperature not specified in the publication | Homo sapiens | naphthalene-1,4-dione | |
1.13.11.52 | 0.0011 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-methylnaphthalene-1,4-dione | |
1.13.11.52 | 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | 8-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione | |
1.13.11.52 | 0.00292 | - |
pH and temperature not specified in the publication | Homo sapiens | 9-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione | |
1.13.11.52 | 0.00396 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-hydroxy-4-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione | |
1.13.11.52 | 0.00495 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,2-dimethyl-1a,9b-dihydro-2H-benzo[g]oxireno[c]chromene-4,9-dione | |
1.13.11.52 | 0.026 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-fluoro-2-(1H-pyrazol-3-yl)phenol | |
1.13.11.52 | 0.038 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[2-(methylsulfanyl)phenyl]-1H-imidazole | |
1.13.11.52 | 0.073 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[3-(methylsulfanyl)phenyl]-1H-imidazole | |
1.13.11.52 | 0.179 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-(2-fluorophenyl)-1H-imidazole | |
1.13.11.52 | 0.422 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-(thiophen-2-yl)-1H-imidazole | |
1.13.11.52 | 0.825 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(1H-imidazol-4-yl)benzaldehyde |