Literature summary extracted from

Koukoulitsa, C.; Bailly, F.; Pegklidou, K.; Demopoulos, V.J.; Cotelle, P.
Evaluation of aldose reductase inhibition and docking studies of 6-nitro and 6,6-dinitrorosmarinic acids (2010), Eur. J. Med. Chem., 45, 1663-1666.

Application

EC Number	Application	Comment	Organism
1.1.1.21	medicine	aldose reductase ALR2 is a target enzyme for the treatment of diabetic complications	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.21	6',6''-dinitrorosmarinic acid	docking structure with ALR2, overview	Homo sapiens
1.1.1.21	6'-nitrorosmarinic acid	docking structure with ALR2, overview	Homo sapiens
1.1.1.21	rosmarinic acid	docking structure with ALR2, overview	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.21	Homo sapiens	P15121	ALR2	-

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.21	aldose reductase	-	Homo sapiens
1.1.1.21	ALR2	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
1.1.1.21	metabolism	aldose reductase ALR2 acts in the polyol metabolic pathway	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)