Literature summary extracted from

Fiesel, F.C.; Voigt, A.; Weber, S.S.; Van den Haute, C.; Waldenmaier, A.; Goerner, K.; Walter, M.; Anderson, M.L.; Kern, J.V.; Rasse, T.M.; Schmidt, T.; Springer, W.; Kirchner, R.; Bonin, M.; Neumann, M.; Baekelandt, V.; Alunni-Fabbroni, M.; Schulz, J.B.; Kahle, P.J.
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 (2010), EMBO J., 29, 209-221.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.1.98	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.5.1.98	HEK-293-EBNA cell	-	Homo sapiens	-
3.5.1.98	SH-SY5Y cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.1.98	acetyl-tubulin + H2O	major HDAC6 substrate	Homo sapiens	tubulin + acetate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.1.98	HDAC6	-	Homo sapiens
3.5.1.98	histone deacetylase 6	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
3.5.1.98	Homo sapiens	knockdown of transactive response DNA-binding protein TDP-43 downregulates histone deacetylase 6 mRNA and protein expression and reduces HDAC6 enzyme activity in non-neuronal as well as in neuronal cells	down

General Information

EC Number	General Information	Comment	Organism
3.5.1.98	physiological function	HDAC6 is necessary for protein aggregate formation and degradation	Homo sapiens

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Release 2023.1 (January 2023)