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Literature summary extracted from

  • Dalvie, D.; Zhang, C.; Chen, W.; Smolarek, T.; Obach, R.S.; Loi, C.M.
    Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences (2010), Drug Metab. Dispos., 38, 641-654.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.3.1 menadione specific inhibitor of aldehyde oxidase Homo sapiens
1.2.3.1 raloxifene specific inhibitor of aldehyde oxidase, complete inhibition at 0.01 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.3.1 0.0034
-
 zoniporide in 25 mM phosphate buffer at 37°C, pH not specified in the publication Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.3.1 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 zoniporide + H2O + O2 i.e. 1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl guanidine Homo sapiens 2-oxozoniporide + H2O2
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.2.3.1 0.0098
-
 in 25 mM phosphate buffer at 37°C, pH not specified in the publication Homo sapiens menadione
1.2.3.1 12
-
 in 25 mM phosphate buffer at 37°C, pH not specified in the publication Homo sapiens raloxifene