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Literature summary extracted from
- Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials (2010), Curr. Med. Chem., 17, 672-697.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.1.1.27 | drug development | the parasite enzyme is a potential target for antimalarial drugs | Plasmodium falciparum |
| 1.1.1.27 | medicine | the enzyme is a target for treatment of cancer | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.27 | the single gene encoding the enzyme is located on chromosome 13 | Plasmodium falciparum |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.1.1.27 | additional information | knockdown of LDH-A by shRNA | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.27 | (abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid | - |
Bos taurus |  |
| 1.1.1.27 | (abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | (abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | (benzylamino)(oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | (benzylamino)(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | (benzylamino)(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | (heptylamino)(oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | (heptylamino)(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | (heptylamino)(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | (hexylamino)(oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | (hexylamino)(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | (hexylamino)(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | (nonylamino)(oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | (nonylamino)(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | (nonylamino)(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | ([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | ([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | ([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 1-[7-[3,4-dihydroxy-2-imino-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-8-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalen-1-yl]ethanone | - |
Homo sapiens | |
| 1.1.1.27 | 1-[7-[3,4-dihydroxy-2-imino-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-8-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalen-1-yl]ethanone | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-4,6,7-trimethylnaphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-4,6,7-trimethylnaphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-6,7-dimethyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-6,7-dimethyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-6,7-dimethyl-4-propylnaphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-6,7-dimethyl-4-propylnaphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-4-(propan-2-yl)-7-[4-(trifluoromethyl)benzyl]naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-4-(propan-2-yl)-7-[4-(trifluoromethyl)benzyl]naphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-7-(2-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-7-(2-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-7-(3-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-7-(3-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-7-(4-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 2,3-dihydroxy-6-methyl-7-(4-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 3,5-dihydroxynaphthalene-2-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 3,5-dihydroxynaphthalene-2-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 3,7-dihydroxynaphthalene-2-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 3,7-dihydroxynaphthalene-2-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 3-(3-nitro-4-pyridyl)pyruvate | - |
Homo sapiens | |
| 1.1.1.27 | 3-(3-nitropyridin-4-yl)-2-oxopropanoic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 3-hydroxy-1,2-oxazole-4-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 3-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one | - |
Plasmodium falciparum | |
| 1.1.1.27 | 3-hydroxy-2-oxo-1-oxaspiro[4,5]-dec-3-ene | - |
Homo sapiens | |
| 1.1.1.27 | 4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 4-(ethylcarbamoyl)benzoic acid | - |
Homo sapiens | |
| 1.1.1.27 | 4-(ethylcarbamoyl)benzoic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 4-hydroxy-1,2-oxazole-3-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 6,6'-disulfanediyldipyridine-3-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 6,6'-disulfanediyldipyridine-3-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 7-(4-chlorobenzyl)-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 7-(4-chlorobenzyl)-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 7-benzyl-2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 7-benzyl-2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 7-benzyl-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 7-benzyl-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8'-acetyl-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 8'-acetyl-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl acetate | - |
Homo sapiens | |
| 1.1.1.27 | 8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl acetate | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl butanoate | - |
Homo sapiens | |
| 1.1.1.27 | 8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl butanoate | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl pentanoate | - |
Homo sapiens | |
| 1.1.1.27 | 8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl pentanoate | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl propanoate | - |
Homo sapiens | |
| 1.1.1.27 | 8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl propanoate | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | - |
Bos taurus | |
| 1.1.1.27 | 8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8-(phenylamino)naphthalene-1-sulfonic acid | - |
Homo sapiens | |
| 1.1.1.27 | 8-(phenylamino)naphthalene-1-sulfonic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | - |
Bos taurus | |
| 1.1.1.27 | 8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | 8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | 8-[8-acetyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-3,4-dihydroxy-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-2-one | - |
Homo sapiens | |
| 1.1.1.27 | 8-[8-acetyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-3,4-dihydroxy-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-2-one | - |
Plasmodium falciparum | |
| 1.1.1.27 | amino(oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | amino(oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | amino(oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | bis(acetatato-kO)(biphenyl-2,2'-diyl-k2C2,C2')copper | - |
Homo sapiens | |
| 1.1.1.27 | bis(acetatato-kO)(biphenyl-2,2'-diyl-k2C2,C2')copper | - |
Plasmodium falciparum | |
| 1.1.1.27 | bis(acetatato-kO)(biphenyl-2,2'-diyl-k2C2,C2')zinc | - |
Homo sapiens | |
| 1.1.1.27 | bis(acetatato-kO)(biphenyl-2,2'-diyl-k2C2,C2')zinc | - |
Plasmodium falciparum | |
| 1.1.1.27 | ethyl 3-(3-cyano-4-pyridyl)pyruvate | - |
Homo sapiens | |
| 1.1.1.27 | ethyl 3-(3-cyanopyridin-4-yl)-2-oxopropanoate | - |
Plasmodium falciparum | |
| 1.1.1.27 | gossypol | - |
Homo sapiens | |
| 1.1.1.27 | gossypol | a polyphenolic binaphthyl disesquiterpene from Gossypium sp. | Plasmodium falciparum | |
| 1.1.1.27 | naphthalene-2,6-dicarboxylic acid | - |
Homo sapiens | |
| 1.1.1.27 | naphthalene-2,6-dicarboxylic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | naphthalene-2,6-disulfonic acid | - |
Homo sapiens | |
| 1.1.1.27 | naphthalene-2,6-disulfonic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo(pentadecylamino)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo(pentadecylamino)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo(pentadecylamino)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo(phenylamino)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo(phenylamino)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo(phenylamino)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo[(2-phenylethyl)amino]acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo[(2-phenylethyl)amino]acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo[(2-phenylethyl)amino]acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo[(2-phenylpropyl)amino]acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo[(2-phenylpropyl)amino]acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo[(2-phenylpropyl)amino]acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo[(3-phenylpropyl)amino]acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo[(3-phenylpropyl)amino]acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo[(3-phenylpropyl)amino]acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo[(4-phenylbutan-2-yl)amino]acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo[(4-phenylbutan-2-yl)amino]acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo[(4-phenylbutan-2-yl)amino]acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo[(4-phenylbutyl)amino]acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo[(4-phenylbutyl)amino]acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo[(4-phenylbutyl)amino]acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid | - |
Bos taurus | |
| 1.1.1.27 | oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(2-ethylphenyl)(phenyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(2-ethylphenyl)(phenyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(2-ethylphenyl)(phenyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(2-methoxyethyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(2-methoxyethyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(2-methoxyethyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(3,3-diphenylpropyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(3,3-diphenylpropyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(3,3-diphenylpropyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(3-methoxypropyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(3-methoxypropyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(3-methoxypropyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(3-methylbutyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(3-methylbutyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(3-methylbutyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(3-methylphenyl)(phenyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(3-methylphenyl)(phenyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(3-methylphenyl)(phenyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(4-chlorobenzyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(4-chlorobenzyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(4-chlorobenzyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(4-methylbenzyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(4-methylbenzyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(4-methylbenzyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [(naphthalen-1-ylmethyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [(naphthalen-1-ylmethyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [(naphthalen-1-ylmethyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [benzyl(methyl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [benzyl(methyl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [benzyl(methyl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid | - |
Plasmodium falciparum | |
| 1.1.1.27 | [[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid | - |
Bos taurus | |
| 1.1.1.27 | [[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid | - |
Homo sapiens | |
| 1.1.1.27 | [[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid | - |
Plasmodium falciparum | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.27 | L-lactate + NAD+ | Homo sapiens | - |
pyruvate + NADH + H+ | - |
r | |
| 1.1.1.27 | L-lactate + NAD+ | Bos taurus | - |
pyruvate + NADH + H+ | - |
r | |
| 1.1.1.27 | L-lactate + NAD+ | Plasmodium falciparum | - |
pyruvate + NADH + H+ | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.27 | Bos taurus | - |
- |
- |
| 1.1.1.27 | Homo sapiens | - |
several isozymes, overview | - |
| 1.1.1.27 | Plasmodium falciparum | - |
several isozymes | - |
| 1.1.1.27 | Plasmodium malariae | - |
several isozymes | - |
| 1.1.1.27 | Plasmodium ovale | - |
several isozymes | - |
| 1.1.1.27 | Plasmodium vivax | - |
several isozymes | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.1.1.27 | (S)-lactate + NAD+ = pyruvate + NADH + H+ | the enzyme-NADH-pyruvate ternery complex undergoes a rate-limiting conformational change, in which the substrate loop closes to form a desolvated ternary complex in order to bring the catalytic residue Arg109 into the active site, the catalytic residues Arg109, Asp168, and His195 are highly conserved, catalyic mechanism, detailed overview | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.27 | heart | - |
Bos taurus | - |
| 1.1.1.27 | liver | - |
Homo sapiens | - |
| 1.1.1.27 | additional information | homo- and heterotetrameric isozymes with tissue-specific expression | Homo sapiens | - |
| 1.1.1.27 | skeletal muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.27 | L-lactate + NAD+ | - |
Homo sapiens | pyruvate + NADH + H+ | - |
r | |
| 1.1.1.27 | L-lactate + NAD+ | - |
Bos taurus | pyruvate + NADH + H+ | - |
r | |
| 1.1.1.27 | L-lactate + NAD+ | - |
Plasmodium falciparum | pyruvate + NADH + H+ | - |
r | |
| 1.1.1.27 | L-lactate + NAD+ | amino acid residues involved in substrate and cofactor binding are Arg109, Asp168, Arg171, and His195 | Plasmodium falciparum | pyruvate + NADH + H+ | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.27 | More | Rossmann fold topology, structure comparison to the enzyme from Homo sapiens, PDB IDs 1i10 and 1ldg, differences occur mainly in the N-terminus, overview | Plasmodium falciparum |
| 1.1.1.27 | More | structure comparison of LDH-M and LDH-H subunit isoforms, the homotetramers have essentially the same tertiary structure, while the hybrid tetramers show different structures, overview. Rossmann fold topology, structure comparison to the enzyme from Plasmodium falciparum, PDB IDs 1i10 and 1ldg, Ser163 is a highly conserved residue amongst human hLDH isozymes, corresponds to Leu163 in PfLDH, differences occur mainly in the N-terminus, overview | Homo sapiens |
| 1.1.1.27 | tetramer | homo- and heterotetrameric isozymes with tissue-specific expression | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.27 | lactate dehydrogenase | - |
Homo sapiens |
| 1.1.1.27 | lactate dehydrogenase | - |
Bos taurus |
| 1.1.1.27 | lactate dehydrogenase | - |
Plasmodium falciparum |
| 1.1.1.27 | lactate dehydrogenase | - |
Plasmodium vivax |
| 1.1.1.27 | lactate dehydrogenase | - |
Plasmodium malariae |
| 1.1.1.27 | lactate dehydrogenase | - |
Plasmodium ovale |
| 1.1.1.27 | LDH | - |
Homo sapiens |
| 1.1.1.27 | LDH-A | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.27 | NAD+ | - |
Bos taurus | |
| 1.1.1.27 | NAD+ | - |
Plasmodium falciparum | |
| 1.1.1.27 | NAD+ | binding structure, overview | Homo sapiens | |
| 1.1.1.27 | NADH | - |
Homo sapiens | |
| 1.1.1.27 | NADH | - |
Bos taurus | |
| 1.1.1.27 | NADH | - |
Plasmodium falciparum | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.27 | 0.00003 | - |
2,3-dihydroxy-6-methyl-7-(4-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.00005 | - |
7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0001 | - |
2,3-dihydroxy-6,7-dimethyl-4-propylnaphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0001 | - |
2,3-dihydroxy-6,7-dimethyl-4-propylnaphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0002 | - |
2,3-dihydroxy-6-methyl-4-(propan-2-yl)-7-[4-(trifluoromethyl)benzyl]naphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0002 | - |
7-benzyl-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0002 | - |
2,3-dihydroxy-6-methyl-7-(3-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0003 | - |
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl pentanoate | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0003 | - |
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl pentanoate | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0003 | - |
7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0004 | - |
8-[8-acetyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-3,4-dihydroxy-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-2-one | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0005 | - |
7-benzyl-2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0006 | - |
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl butanoate | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0006 | - |
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl butanoate | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0006 | - |
8-[8-acetyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-3,4-dihydroxy-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-2-one | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0007 | - |
gossypol | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0007 | - |
7-benzyl-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0008 | - |
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl acetate | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0008 | - |
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl acetate | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.001 | - |
2,3-dihydroxy-6,7-dimethyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.001 | - |
2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.001 | - |
7-(4-chlorobenzyl)-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0011 | - |
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl propanoate | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0011 | - |
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl propanoate | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0012 | - |
8'-acetyl-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.0013 | - |
8'-acetyl-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0014 | - |
gossypol | LDH-B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0019 | - |
gossypol | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.002 | - |
2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.002 | - |
2,3-dihydroxy-6,7-dimethyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0025 | - |
1-[7-[3,4-dihydroxy-2-imino-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-8-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalen-1-yl]ethanone | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.003 | - |
2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.003 | - |
2,3-dihydroxy-6-methyl-7-(2-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.004 | - |
2,3-dihydroxy-4,6,7-trimethylnaphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.0042 | - |
gossypol | LDH-C, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.006 | - |
2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.008 | - |
7-benzyl-2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.013 | - |
2,3-dihydroxy-4,6,7-trimethylnaphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.013 | - |
2,3-dihydroxy-6-methyl-4-(propan-2-yl)-7-[4-(trifluoromethyl)benzyl]naphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.016 | - |
1-[7-[3,4-dihydroxy-2-imino-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-8-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalen-1-yl]ethanone | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.022 | - |
2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.1.1.27 | 0.034 | - |
2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.4 | - |
(benzylamino)(oxo)acetic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.8 | - |
oxo[(4-phenylbutan-2-yl)amino]acetic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 0.9 | - |
oxo[(3-phenylpropyl)amino]acetic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 1 | - |
[(4-chlorobenzyl)amino](oxo)acetic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 2 | - |
oxo[(4-phenylbutyl)amino]acetic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 2 | - |
[(4-methylbenzyl)amino](oxo)acetic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 7 | - |
oxo[(2-phenylethyl)amino]acetic acid | LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 10 | - |
oxo(phenylamino)acetic acid | above, LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 1.1.1.27 | 10 | - |
oxo[(2-phenylpropyl)amino]acetic acid | above, LDH-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.27 | 0.000035 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | oxo[(3-phenylpropyl)amino]acetic acid | |
| 1.1.1.27 | 0.00007 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(4-chlorobenzyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.00008 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | (benzylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.00009 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(4-methylbenzyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.0001 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | oxo[(2-phenylethyl)amino]acetic acid | |
| 1.1.1.27 | 0.00014 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid | |
| 1.1.1.27 | 0.00065 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid | |
| 1.1.1.27 | 0.0011 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 3-hydroxy-1,2-oxazole-4-carboxylic acid | |
| 1.1.1.27 | 0.00175 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid | |
| 1.1.1.27 | 0.0031 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | |
| 1.1.1.27 | 0.0083 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | ([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | |
| 1.1.1.27 | 0.0114 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid | |
| 1.1.1.27 | 0.014 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(2-methoxyethyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.016 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 4-hydroxy-1,2-oxazole-3-carboxylic acid | |
| 1.1.1.27 | 0.0188 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid | |
| 1.1.1.27 | 0.02 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | (abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.025 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [(2-methoxyethyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.031 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [(3-methoxypropyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.032 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.035 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(3,3-diphenylpropyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.041 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | oxo[(4-phenylbutyl)amino]acetic acid | |
| 1.1.1.27 | 0.043 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(naphthalen-1-ylmethyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.043 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(3-methoxypropyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.043 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.046 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.047 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | (hexylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.051 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid | |
| 1.1.1.27 | 0.059 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | (abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.059 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.0873 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | |
| 1.1.1.27 | 0.088 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | oxo[(4-phenylbutyl)amino]acetic acid | |
| 1.1.1.27 | 0.088 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | (nonylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.09 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [(3,3-diphenylpropyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.0944 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | amino(oxo)acetic acid | |
| 1.1.1.27 | 0.0979 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(3-methylphenyl)(phenyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.101 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.107 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [(3-methylphenyl)(phenyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.116 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | amino(oxo)acetic acid | |
| 1.1.1.27 | 0.133 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | (hexylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.146 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid | |
| 1.1.1.27 | 0.15 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | oxo(pentadecylamino)acetic acid | |
| 1.1.1.27 | 0.157 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(3-methylbutyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.158 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [(2-ethylphenyl)(phenyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.16 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | (heptylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.168 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [benzyl(methyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.169 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.179 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | ([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | |
| 1.1.1.27 | 0.186 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | [(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.187 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid | |
| 1.1.1.27 | 0.191 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(2-ethylphenyl)(phenyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Bos taurus | (heptylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | oxo(pentadecylamino)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Bos taurus | [(naphthalen-1-ylmethyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Bos taurus | (nonylamino)(oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [benzyl(methyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | [bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Bos taurus | [(3-methylbutyl)amino](oxo)acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Bos taurus | oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Bos taurus | oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid | |
| 1.1.1.27 | 0.2 | - |
above, pH not specified in the publication, temperature not specified in the publication | Bos taurus | [[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid | |
| 1.1.1.27 | 0.225 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | |
| 1.1.1.27 | 0.232 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | |
| 1.1.1.27 | 0.31 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid | |
| 1.1.1.27 | 0.52 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 8-(phenylamino)naphthalene-1-sulfonic acid | |
| 1.1.1.27 | 1.1 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 8-(phenylamino)naphthalene-1-sulfonic acid | |
| 1.1.1.27 | 1.4 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | naphthalene-2,6-dicarboxylic acid | |
| 1.1.1.27 | 1.7 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 3,5-dihydroxynaphthalene-2-carboxylic acid | |
| 1.1.1.27 | 2.4 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 3,7-dihydroxynaphthalene-2-carboxylic acid | |
| 1.1.1.27 | 4.6 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 6,6'-disulfanediyldipyridine-3-carboxylic acid | |
| 1.1.1.27 | 5 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3,7-dihydroxynaphthalene-2-carboxylic acid | |
| 1.1.1.27 | 5.11 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | naphthalene-2,6-dicarboxylic acid | |
| 1.1.1.27 | 5.9 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid | |
| 1.1.1.27 | 6.6 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 6,6'-disulfanediyldipyridine-3-carboxylic acid | |
| 1.1.1.27 | 9.8 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | naphthalene-2,6-disulfonic acid | |
| 1.1.1.27 | 21 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | naphthalene-2,6-disulfonic acid | |
| 1.1.1.27 | 150 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3,5-dihydroxynaphthalene-2-carboxylic acid | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.1.27 | metabolism | LDH plays a central role in several metabolic pathways, e.g. in energy production in glycolysis, in gluconeogenesis. Glycolytic process, overview | Homo sapiens |
| 1.1.1.27 | additional information | the enzyme is involved in development of cancer, especially of hypoxic cancer cells, since the cancer cells relay on LDH-A for the energy supply. The glycolytic phenotype is responsible for the tumorigenicity of hypoxic cells | Homo sapiens |
| 1.1.1.27 | physiological function | LDH-A deficiency causes myoglobinuria | Homo sapiens |
| 1.1.1.27 | physiological function | the parasite's ATP production is almost completely dependent on the glucose metabolism and the glycolytic pathway, that is absent in normal human host cells, overview. PfLDH plays the essential role in NAD+ regenration needed for the continuity of the glycolytic cycle | Plasmodium falciparum |
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Release 2023.1 (January 2023)
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