Literature summary extracted from

Rademaker, M.T.; Charles, C.J.; Nicholls, M.G.; Richards, A.M.
Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure (2009), Circulation, 2, 532-540.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.23.15	angiotensinogen + H2O	Ovis aries	-	angiotensin I + angiotensinogen propeptide	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.23.15	Ovis aries	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.23.15	blood plasma	-	Ovis aries	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.23.15	angiotensinogen + H2O	-	Ovis aries	angiotensin I + angiotensinogen propeptide	-	?

Expression

EC Number	Organism	Comment	Expression
3.4.23.15	Ovis aries	treatment with 0.05 mg urocortin 2 or 0.05 mg urocortin 2 plus 20 mg furosemide markedly reduces plasma renin activity	down
3.4.23.15	Ovis aries	20 mg furosemide induces activation of renin	up

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Release 2023.1 (January 2023)