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Literature summary extracted from

  • Srivastava, S.; Vladykovskaya, E.; Barski, O.A.; Spite, M.; Kaiserova, K.; Petrash, J.M.; Chung, S.S.; Hunt, G.; Dawn, B.; Bhatnagar, A.
    Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice (2009), Circ. Res., 105, 793-802.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 sorbinil
-
 Mus musculus
1.1.1.21 Tolrestat
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Mus musculus
-
 apolipoprotein E-null mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 aorta
-
 Mus musculus
-
1.1.1.21 blood vessel
-
 Mus musculus
-
1.1.1.21 smooth muscle
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.1.1.21 physiological function aldose reductase metabolizes both free and phospholipid aldehydes and exacerbates atherosclerotic lesion formation, increase in lesion area attributable to inhibition of the enzyme or deletion of the gene encoding the enzyme occurs in both male and female mice, phenotype of enzyme-deficient male and female mice with increases in arterial lesions, macrophage accumulation and interstitial fibrosis, and decreases smooth muscle cell content of arterial lesions, detailed overview Mus musculus