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Literature summary extracted from

  • Eberle, C.; Lauber, B.S.; Fankhauser, D.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.L.; Diederich, F.
    Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities (2011), ChemMedChem, 6, 292-301.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.12 1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
-
 Leishmania donovani
1.8.1.12 1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
-
 Plasmodium falciparum
1.8.1.12 1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine 36% inhibition at 0.1 mM Trypanosoma cruzi
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
-
 Leishmania donovani
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
-
 Plasmodium falciparum
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
-
 Trypanosoma cruzi
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
-
 Leishmania donovani
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
-
 Plasmodium falciparum
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
-
 Trypanosoma cruzi
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
 Leishmania donovani
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
 Plasmodium falciparum
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
-
 Trypanosoma cruzi
1.8.1.12 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
-
 Leishmania donovani
1.8.1.12 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
-
 Plasmodium falciparum
1.8.1.12 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate 86% inhibition at 0.04 mM Trypanosoma cruzi
1.8.1.12 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
-
 Leishmania donovani
1.8.1.12 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
-
 Plasmodium falciparum
1.8.1.12 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate 52% inhibition at 0.04 mM Trypanosoma cruzi
1.8.1.12 1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
-
 Leishmania donovani
1.8.1.12 1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
-
 Plasmodium falciparum
1.8.1.12 1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine 16% inhibition at 0.1 mM Trypanosoma cruzi
1.8.1.12 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
-
 Leishmania donovani
1.8.1.12 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
-
 Plasmodium falciparum
1.8.1.12 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine 28% inhibition at 0.1 mM Trypanosoma cruzi
1.8.1.12 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
-
 Leishmania donovani
1.8.1.12 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
-
 Plasmodium falciparum
1.8.1.12 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine 28% inhibition at 0.1 mM Trypanosoma cruzi
1.8.1.12 1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
-
 Leishmania donovani
1.8.1.12 1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
-
 Plasmodium falciparum
1.8.1.12 1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine 25% inhibition at 0.1 mM Trypanosoma cruzi
1.8.1.12 2-(1-cyclopentylcyclohexyl)-1-benzothiophene
-
 Leishmania donovani
1.8.1.12 2-(1-cyclopentylcyclohexyl)-1-benzothiophene
-
 Plasmodium falciparum
1.8.1.12 2-(1-cyclopentylcyclohexyl)-1-benzothiophene
-
 Trypanosoma brucei rhodesiense
1.8.1.12 2-(1-cyclopentylcyclohexyl)-1-benzothiophene 61% inhibition at 0.04 mM Trypanosoma cruzi
1.8.1.12 2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
 Leishmania donovani
1.8.1.12 2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
 Plasmodium falciparum
1.8.1.12 2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
 Trypanosoma brucei rhodesiense
1.8.1.12 2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline 58% inhibition at 0.1 mM Trypanosoma cruzi
1.8.1.12 2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
 Leishmania donovani
1.8.1.12 2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
 Plasmodium falciparum
1.8.1.12 2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
-
 Trypanosoma brucei rhodesiense
1.8.1.12 2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline 42% inhibition at 0.1 mM Trypanosoma cruzi
1.8.1.12 N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
-
 Leishmania donovani
1.8.1.12 N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
-
 Plasmodium falciparum
1.8.1.12 N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
-
 Trypanosoma brucei rhodesiense
1.8.1.12 N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine 46% inhibition at 0.1 mM Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Leishmania donovani
-
-
-
1.8.1.12 Plasmodium falciparum
-
-
-
1.8.1.12 Trypanosoma brucei rhodesiense
-
-
-
1.8.1.12 Trypanosoma cruzi P28593
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Leishmania donovani trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Plasmodium falciparum trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Trypanosoma brucei rhodesiense trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Trypanosoma cruzi trypanothione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.12 trypanothione reductase
-
 Leishmania donovani
1.8.1.12 trypanothione reductase
-
 Plasmodium falciparum
1.8.1.12 trypanothione reductase
-
 Trypanosoma brucei rhodesiense
1.8.1.12 trypanothione reductase
-
 Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 FAD
-
 Leishmania donovani
1.8.1.12 FAD
-
 Plasmodium falciparum
1.8.1.12 FAD
-
 Trypanosoma brucei rhodesiense
1.8.1.12 FAD
-
 Trypanosoma cruzi
1.8.1.12 NADPH
-
 Leishmania donovani
1.8.1.12 NADPH
-
 Plasmodium falciparum
1.8.1.12 NADPH
-
 Trypanosoma brucei rhodesiense
1.8.1.12 NADPH
-
 Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.12 0.0011
-
 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine at 25°C, pH not specified in the publication Trypanosoma cruzi
1.8.1.12 0.002
-
 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate at 25°C, pH not specified in the publication Trypanosoma cruzi
1.8.1.12 0.005
-
 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate at 25°C, pH not specified in the publication Trypanosoma cruzi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.12 0.00009
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
1.8.1.12 0.00012
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
1.8.1.12 0.00013
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
1.8.1.12 0.00023
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
1.8.1.12 0.00023
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
1.8.1.12 0.00028
-
 at 25°C, pH not specified in the publication Plasmodium falciparum N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
1.8.1.12 0.00032
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
1.8.1.12 0.00039
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
1.8.1.12 0.00082
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
1.8.1.12 0.00088
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
1.8.1.12 0.00088
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
1.8.1.12 0.0011
-
 at 25°C, pH not specified in the publication Leishmania donovani 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
1.8.1.12 0.0013
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
1.8.1.12 0.0016
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
1.8.1.12 0.00173
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
1.8.1.12 0.00186
-
 at 25°C, pH not specified in the publication Leishmania donovani 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
1.8.1.12 0.00211
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
1.8.1.12 0.00233
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
1.8.1.12 0.0024
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
1.8.1.12 0.00253
-
 at 25°C, pH not specified in the publication Leishmania donovani 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
1.8.1.12 0.00323
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
1.8.1.12 0.00327
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
1.8.1.12 0.00401
-
 at 25°C, pH not specified in the publication Leishmania donovani 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
1.8.1.12 0.00424
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
1.8.1.12 0.00458
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
1.8.1.12 0.00627
-
 at 25°C, pH not specified in the publication Plasmodium falciparum 2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
1.8.1.12 0.00633
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
1.8.1.12 0.00656
-
 at 25°C, pH not specified in the publication Leishmania donovani N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
1.8.1.12 0.0106
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
1.8.1.12 0.0116
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
1.8.1.12 0.0122
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
1.8.1.12 0.0239
-
 at 25°C, pH not specified in the publication Leishmania donovani 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
1.8.1.12 0.025
-
 at 25°C, pH not specified in the publication Trypanosoma brucei rhodesiense 1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
1.8.1.12 0.0337
-
 at 25°C, pH not specified in the publication Leishmania donovani 1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
1.8.1.12 0.05212
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
1.8.1.12 0.0539
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
1.8.1.12 0.0759
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
1.8.1.12 0.112
-
 at 25°C, pH not specified in the publication Leishmania donovani 2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
1.8.1.12 0.115
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
1.8.1.12 0.162
-
 at 25°C, pH not specified in the publication Trypanosoma cruzi 2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
1.8.1.12 0.18
-
 at 25°C, pH not specified in the publication Leishmania donovani 2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
1.8.1.12 0.194
-
 at 25°C, pH not specified in the publication Leishmania donovani 1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine