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Literature summary extracted from

  • Bleif, S.; Hannemann, F.; Lisurek, M.; Von Kries, J.; Zapp, J.; Dietzen, M.; Antes, I.; Bernhardt, R.
    Identification of CYP106A2 as a regioselective allylic bacterial diterpene hydroxylase (2011), ChemBioChem, 12, 576-582.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.15.8 additional information construction of a CYP106A2 knockout strain Priestia megaterium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.8 additional information Priestia megaterium CYP106A2 catalyzes hydroxylations of a variety of 3-oxo-D4-steroids such as progesterone and deoxycorticosterone, mainly in the 15beta-position. The diterpene resin acid abietic acid is a substrate, that is converted to 12alpha- and 12beta-hydroxyabietic acid, catalytic site binding structure, homology modelling, overview ?
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 ?
1.14.15.8 additional information Priestia megaterium ATCC 13368 CYP106A2 catalyzes hydroxylations of a variety of 3-oxo-D4-steroids such as progesterone and deoxycorticosterone, mainly in the 15beta-position. The diterpene resin acid abietic acid is a substrate, that is converted to 12alpha- and 12beta-hydroxyabietic acid, catalytic site binding structure, homology modelling, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.8 Priestia megaterium Q06069
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1.14.15.8 Priestia megaterium ATCC 13368 Q06069
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.8 additional information CYP106A2 catalyzes hydroxylations of a variety of 3-oxo-D4-steroids such as progesterone and deoxycorticosterone, mainly in the 15beta-position. The diterpene resin acid abietic acid is a substrate, that is converted to 12alpha- and 12beta-hydroxyabietic acid, catalytic site binding structure, homology modelling, overview Priestia megaterium ?
-
 ?
1.14.15.8 additional information high-throughput substrate screening and binding affinities, substrate docking, overview Priestia megaterium ?
-
 ?
1.14.15.8 additional information CYP106A2 catalyzes hydroxylations of a variety of 3-oxo-D4-steroids such as progesterone and deoxycorticosterone, mainly in the 15beta-position. The diterpene resin acid abietic acid is a substrate, that is converted to 12alpha- and 12beta-hydroxyabietic acid, catalytic site binding structure, homology modelling, overview Priestia megaterium ATCC 13368 ?
-
 ?
1.14.15.8 additional information high-throughput substrate screening and binding affinities, substrate docking, overview Priestia megaterium ATCC 13368 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.8 CYP106A2
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 Priestia megaterium