Any feedback?
Literature summary extracted from
- Sesquiterpenes from cultures of the basidiomycete Clitocybe conglobata and their 11 beta-hydroxysteroid dehydrogenase inhibitory activity (2009), Chem. Pharm. Bull., 57, 433-435.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.B40 | expressed in HEK-293 cell | Mus musculus |
| 1.1.1.B40 | overexpressed in HEK-293 cell | Homo sapiens |
| 1.1.1.146 | expressed in HEK-293 cell | Mus musculus |
| 1.1.1.146 | overexpressed in HEK-293 cell | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.B40 | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Homo sapiens |  |
| 1.1.1.B40 | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Mus musculus | |
| 1.1.1.B40 | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Homo sapiens | |
| 1.1.1.B40 | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Mus musculus | |
| 1.1.1.B40 | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | - |
Homo sapiens | |
| 1.1.1.B40 | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | - |
Mus musculus | |
| 1.1.1.B40 | glycyrrhizininc acid | - |
Homo sapiens | |
| 1.1.1.146 | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Homo sapiens | |
| 1.1.1.146 | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Mus musculus | |
| 1.1.1.146 | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Homo sapiens | |
| 1.1.1.146 | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Mus musculus | |
| 1.1.1.146 | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | - |
Homo sapiens | |
| 1.1.1.146 | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | - |
Mus musculus | |
| 1.1.1.146 | glycyrrhizininc acid | - |
Homo sapiens | |
| 1.1.1.146 | glycyrrhizininc acid | - |
Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.B40 | microsome | - |
Mus musculus | - |
- |
| 1.1.1.B40 | microsome | - |
Homo sapiens | - |
- |
| 1.1.1.146 | microsome | - |
Mus musculus | - |
- |
| 1.1.1.146 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.B40 | Homo sapiens | - |
- |
- |
| 1.1.1.B40 | Mus musculus | - |
- |
- |
| 1.1.1.146 | Homo sapiens | - |
- |
- |
| 1.1.1.146 | Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.B40 | cortisol + NAD+ | - |
Mus musculus | cortisone + NADH + H+ | - |
? | |
| 1.1.1.B40 | cortisol + NAD+ | - |
Homo sapiens | cortisone + NADH + H+ | - |
? | |
| 1.1.1.146 | cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? | |
| 1.1.1.146 | cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase 2 | - |
Mus musculus |
| 1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase 2 | - |
Homo sapiens |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase 1 | - |
Mus musculus |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase 1 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.B40 | NAD+ | - |
Mus musculus | |
| 1.1.1.B40 | NAD+ | - |
Homo sapiens | |
| 1.1.1.146 | NADP+ | - |
Mus musculus | |
| 1.1.1.146 | NADP+ | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.B40 | additional information | - |
IC50 = 0.177 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
| 1.1.1.B40 | additional information | - |
IC50 = 0.2 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | |
| 1.1.1.B40 | additional information | - |
IC50 = 0.22 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
| 1.1.1.B40 | additional information | - |
IC50 = 0.2505 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
| 1.1.1.B40 | additional information | - |
IC50 = 0.3303 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
| 1.1.1.B40 | additional information | - |
IC50 = 0.5002 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | |
| 1.1.1.B40 | 0.00000071 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | glycyrrhizininc acid | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0017 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0032 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
| 1.1.1.146 | additional information | - |
IC50 = 0.008 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0107 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0194 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0241 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
| 1.1.1.146 | 0.0000186 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | glycyrrhizininc acid | |
| 1.1.1.146 | 0.0000295 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | glycyrrhizininc acid | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
