BRENDA - Enzyme Database show

5 alpha-reductase and aromatase inhibitory constituents from Brassica rapa L. pollen

Li, Y.H.; Yang, Y.F.; Li, K.; Jin, L.L.; Yang, N.Y.; Kong, D.Y.; Chem. Pharm. Bull. 57, 401-404 (2009)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.3.99.5
linolenic acid
strong inhibition
Rattus norvegicus
1.3.99.5
Monolinolein
strong inhibition
Rattus norvegicus
1.3.99.5
additional information
screening of biologically active constituents from Brassica rapa pollen in supercritical CO2 fluid extract, overview. No inhibition by 24-methylenecholesterol linolenate, cycloeucalenol linolenate, 24-methylenecholesterol palmitate, cycloeucalenol, pollinastanol, 24-methylenecholesterol, palmitic acid, and monopalmitin
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.3.99.5
microsome
-
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.3.99.5
dihydrotestosterone + NADP+
Rattus norvegicus
the enzyme performs conversion of testosterone to dihydrotestosterone
testosterone + NADPH + H+
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.3.99.5
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.3.99.5
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.3.99.5
dihydrotestosterone + NADP+
-
711736
Rattus norvegicus
testosterone + NADPH + H+
-
-
-
r
1.3.99.5
dihydrotestosterone + NADP+
the enzyme performs conversion of testosterone to dihydrotestosterone
711736
Rattus norvegicus
testosterone + NADPH + H+
-
-
-
r
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.3.99.5
linolenic acid
strong inhibition
Rattus norvegicus
1.3.99.5
Monolinolein
strong inhibition
Rattus norvegicus
1.3.99.5
additional information
screening of biologically active constituents from Brassica rapa pollen in supercritical CO2 fluid extract, overview. No inhibition by 24-methylenecholesterol linolenate, cycloeucalenol linolenate, 24-methylenecholesterol palmitate, cycloeucalenol, pollinastanol, 24-methylenecholesterol, palmitic acid, and monopalmitin
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.3.99.5
microsome
-
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.3.99.5
dihydrotestosterone + NADP+
Rattus norvegicus
the enzyme performs conversion of testosterone to dihydrotestosterone
testosterone + NADPH + H+
-
-
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.3.99.5
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.3.99.5
dihydrotestosterone + NADP+
-
711736
Rattus norvegicus
testosterone + NADPH + H+
-
-
-
r
1.3.99.5
dihydrotestosterone + NADP+
the enzyme performs conversion of testosterone to dihydrotestosterone
711736
Rattus norvegicus
testosterone + NADPH + H+
-
-
-
r