EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.5.2.6 | sitting-drop method, crystal structure of the OXA-48 carbapenemase is determined at pH 7.5 and at a resolution of 1.9 A. The enzyme shows a noncrystallographic pseudo 2-fold axis | Klebsiella pneumoniae |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.2.6 | 0.011 | - |
meropenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.013 | - |
Imipenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.013 | - |
faropenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.014 | - |
panipenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.045 | - |
temocillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.095 | - |
Oxacillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.1 | - |
ertapenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.12 | - |
nitrocefin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.195 | - |
cephalothin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.395 | - |
ampicillin | pH 7.0, 30°C | Klebsiella pneumoniae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.2.6 | Klebsiella pneumoniae | Q6XEC0 | the recombinant plasmid pVT-1 is used as a source of the blaOXA-48 gene. The blaOXA-48 ORF is subcloned into expression vector pET-9a to yield recombinant plasmid pET-OXA-48. Escherichia coli MCT236(DE3) is used as the host for overproduction of the OXA-48 enzyme | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.2.6 | - |
Klebsiella pneumoniae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.2.6 | ampicillin + H2O | - |
Klebsiella pneumoniae | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | cefepime + H2O | - |
Klebsiella pneumoniae | (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
3.5.2.6 | cefotaxime + H2O | - |
Klebsiella pneumoniae | (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
3.5.2.6 | cefoxitin + H2O | - |
Klebsiella pneumoniae | (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
3.5.2.6 | ceftazidime + H2O | - |
Klebsiella pneumoniae | (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
3.5.2.6 | cephalothin + H2O | - |
Klebsiella pneumoniae | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
3.5.2.6 | ertapenem + H2O | - |
Klebsiella pneumoniae | (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-([(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl)-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
3.5.2.6 | faropenem + H2O | - |
Klebsiella pneumoniae | (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-tetrahydrofuran-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid | - |
? | |
3.5.2.6 | imipenem + H2O | - |
Klebsiella pneumoniae | (5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
3.5.2.6 | meropenem + H2O | - |
Klebsiella pneumoniae | (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
3.5.2.6 | nitrocefin + H2O | - |
Klebsiella pneumoniae | (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
3.5.2.6 | oxacillin + H2O | - |
Klebsiella pneumoniae | (2R,4S)-2-[(R)-carboxy[[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | panipenem + H2O | - |
Klebsiella pneumoniae | (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S)-1-ethanimidoylpyrrolidin-3-yl]sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
3.5.2.6 | temocillin + H2O | - |
Klebsiella pneumoniae | (2R,4S)-2-[(S)-carboxy[[carboxy(thiophen-3-yl)acetyl]amino]methoxymethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.5.2.6 | dimer | - |
Klebsiella pneumoniae |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.2.6 | OXA-48 carbapenemase | - |
Klebsiella pneumoniae |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.2.6 | 0.038 | - |
faropenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.07 | - |
meropenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.13 | - |
ertapenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 0.3 | - |
temocillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 1.4 | - |
panipenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 4.8 | - |
Imipenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 44 | - |
cephalothin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 130 | - |
Oxacillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 940 | - |
nitrocefin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 955 | - |
ampicillin | pH 7.0, 30°C | Klebsiella pneumoniae |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.2.6 | 0.26 | - |
cefoxitin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 1.1 | - |
cefepime | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 1.3 | - |
ertapenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 2.9 | - |
faropenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 6.2 | - |
meropenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 6.6 | - |
temocillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 10 | - |
cefotaxime | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 100 | - |
panipenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 230 | - |
cephalothin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 370 | - |
Imipenem | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 1400 | - |
Oxacillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 2400 | - |
ampicillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
3.5.2.6 | 7700 | - |
nitrocefin | pH 7.0, 30°C | Klebsiella pneumoniae |