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Literature summary extracted from

  • Nian, H.; Bisson, W.H.; Dashwood, W.M.; Pinto, J.T.; Dashwood, R.H.
    Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells (2009), Carcinogenesis, 30, 1416-1423.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 alpha-keto-gamma-methylselenobutyrate causes dose-dependent inhibition of HDAC activity, HDAC1 shows about 80% residual activity at 2 mM, HDAC8 shows less than 60% residual activity at 2 mM Homo sapiens
3.5.1.98 beta-methylselenopyruvate causes dose-dependent inhibition of HDAC activity, competitive inhibitor of HDAC8, HDAC1 shows about 30% residual activity at 2 mM, HDAC8 shows less than 30% residual activity at 2 mM Homo sapiens
3.5.1.98 Butyrate
-
 Homo sapiens
3.5.1.98 additional information methylselenocysteine and selenomethionine have little or no inhibitory activity up to 2 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.98 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens Q9BY41
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 colonic cancer cell
-
 Homo sapiens
-
3.5.1.98 HCT-116 cell
-
 Homo sapiens
-
3.5.1.98 HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 N-acetyl-lysine-histone H3 + H2O
-
 Homo sapiens acetate + histone H3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC1
-
 Homo sapiens
3.5.1.98 HDAC8
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.98 0.02
-
 HDAC8, at 37°C, pH not specified in the publication Homo sapiens beta-methylselenopyruvate