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Literature summary extracted from

  • Florczyk, U.; Golda, S.; Zieba, A.; Cisowski, J.; Jozkowicz, A.; Dulak, J.
    Overexpression of biliverdin reductase enhances resistance to chemotherapeutics (2010), Cancer Lett., 300, 40-47.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.24 reversible overexpression of BVR in mouse fibroblasts, doxycycline-dependent overexpression of BVR in NIH 3T3 BVR-Tet-On cells confers protection against cytotoxic drugs cisplatin and doxorubicin Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 bilirubin + NAD+ Homo sapiens
-
 biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NADP+ Homo sapiens
-
 biliverdin + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens P53004
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 HaCaT cell
-
 Homo sapiens
-
1.3.1.24 keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 bilirubin + NAD+
-
 Homo sapiens biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 biliverdin reductase A
-
 Homo sapiens
1.3.1.24 BVR
-
 Homo sapiens
1.3.1.24 BVRA
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.24 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.24 6.7
-
 with cofactor NADH Homo sapiens
1.3.1.24 8.7
-
 with cofactor NADPH Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NAD+
-
 Homo sapiens
1.3.1.24 NADH
-
 Homo sapiens
1.3.1.24 NADP+
-
 Homo sapiens
1.3.1.24 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.3.1.24 Homo sapiens doxycycline dose-dependently induces BVR gene expression at the level of mRNA as well as a protein, and BVR activity in genetically modified NIH 3T3 fibroblasts up

General Information

EC Number General Information Comment Organism
1.3.1.24 additional information the BVR activity and expression is not affected by MAP kinase inhibitors, overview Homo sapiens
1.3.1.24 physiological function biliverdin reductase converts biliverdin to bilirubin. Additionally, acting as a transcription factor and possessing a capacity of a serine/threonine kinase, it may modulate signaling pathways. BVR exhibits cytoprotection, important role of PKCa/b kinase in BVR-mediated improvement in cell survival Homo sapiens