Literature summary extracted from

Wei, N.; Sun, H.; Wang, F.; Liu, G.
H1, a novel derivative of tetrandrine reverse P-glycoprotein-mediated multidrug resistance by inhibiting transport function and expression of P-glycoprotein (2011), Cancer Chemother. Pharmacol., 67, 1017-1025.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
7.6.2.2	(1beta,1'beta)-5-bromo-6,6',7,12-tetramethoxy-2-methylberbaman	is an effectively and potential agent in reversing Pgp-mediated multidrug resistance by inhibiting the transport function and expression of Pgp	Homo sapiens
7.6.2.2	tetrandrine	i.e (1beta,1'beta)-6,6',7,12-tetramethoxy-2,2'-dimethylberbaman	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.6.2.2	Homo sapiens	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
7.6.2.2	ubiquitination	H1 prompts the degradation of Pgp and decreases Pgp protein half-life by enhancing the ubiquitination of Pgp	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
7.6.2.2	KBv200 cell	-	Homo sapiens	-
7.6.2.2	MCF-7/adr cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7.6.2.2	ATP + H2O + doxorubicin/in	-	Homo sapiens	ADP + phosphate + doxorubicin/out	-	?
7.6.2.2	ATP + H2O + rhodamine 123/in	-	Homo sapiens	ADP + phosphate + rhodamine 123/out	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
7.6.2.2	Pgp	-	Homo sapiens

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Release 2023.1 (January 2023)