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Literature summary extracted from

  • Cartagena, C.M.; Burns, M.P.; Rebeck, G.W.
    24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury (2010), Brain Res., 1319, 1-12.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Homo sapiens
-
 (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 brain expression of Cyp46 in the brain is altered during normal development but is relatively stable in normal adult brain Homo sapiens
-
1.14.14.25 microglia
-
 Homo sapiens
-
1.14.14.25 neuroblastoma cell
-
 Homo sapiens
-
1.14.14.25 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.25 cholesterol 24S-hydroxylase
-
 Homo sapiens
1.14.14.25 CYP46
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.14.25 Homo sapiens Cyp46 is upregulated in traumatic brain injury, specifically in microglia up

General Information

EC Number General Information Comment Organism
1.14.14.25 metabolism cholesterol 24S-hydroxylase is a cholesterol metabolic enzyme with regulatory function in traumatic brain injury, overview Homo sapiens
1.14.14.25 additional information Cyp46 is upregulated in traumatic brain injury. Membrane damage during traumatic brain injury alters the brain homeostasis of cholesterol and other lipids. Reaction product 24S-hydroxycholesterol decreases mRNA levels of the cholesterol synthesis genes HMG CoA reductase, squalene synthase, and FPP synthase but does not alter levels of the mRNA of fatty acid synthesis genes acetyl CoA carboxylase or fatty acid synthase Homo sapiens
1.14.14.25 physiological function 24S-hydroxycholesterol and LXR agonist TO-901317 both increase SREBP-1 mRNA levels while 24S-hydroxycholesterol decreases SREBP-2 mRNA levels, real-time PCR quantification, overview Homo sapiens