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Literature summary extracted from

  • Arslanova, D.; Yang, T.; Xu, X.; Wong, S.T.; Augelli-Szafran, C.E.; Xia, W.
    Phenotypic analysis of images of zebrafish treated with Alzheimers gamma-secretase inhibitors (2010), BMC Biotechnol., 10, 24.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.46 AD115 a fragment of Gleevec Danio rerio
3.4.23.46 AD28 a fragment of Gleevec Danio rerio
3.4.23.46 AD94 a fragment of Gleevec Danio rerio
3.4.23.46 AD95 a fragment of Gleevec, strong inhibition Danio rerio
3.4.23.46 Gleevec
-
 Danio rerio
3.4.23.46 N- [N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine tert-butyl ester complete inhibition at 0.1 mM Danio rerio

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.46 amyloid precursor protein + H2O Danio rerio
-
 amyloid beta protein 40 + amyloid beta protein 42
-
 ?
3.4.23.46 Notch + H2O Danio rerio
-
 Notch intracellular domain + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.46 Danio rerio
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.46 embryo
-
 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.46 amyloid precursor protein + H2O
-
 Danio rerio amyloid beta protein 40 + amyloid beta protein 42
-
 ?
3.4.23.46 Notch + H2O
-
 Danio rerio Notch intracellular domain + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.46 gamma-secretase
-
 Danio rerio