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Literature summary extracted from

  • Dairaku, I.; Han, Y.; Yanaka, N.; Kato, N.
    Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents (2010), Biosci. Biotechnol. Biochem., 74, 185-187.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.205 isoform IMPDH2, expression in Escherichia coli Homo sapiens
1.1.1.205 isoform IMPDH2, expression in Escherichia coli Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 chlorogenic acid 0.1 mM, 30% inhibition Mus musculus
1.1.1.205 curcumin significantly reduces the level of GTP and reduces the rate of cell growth Homo sapiens
1.1.1.205 curcumin 0.1 mM, 68% inhibition, both competitive and uncompetitive Mus musculus
1.1.1.205 ellagic acid 0.1 mM, 27% inhibition Mus musculus
1.1.1.205 epigallocatechin gallate 0.1 mM, 47% inhibition Mus musculus
1.1.1.205 additional information not inhibitory: resveratrol, genistein, eugenol, gingerol, naringenin, naringin, caffeic acid, morin, kaempferol, hesperidin, rosmarinic acid Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.205 0.0509
-
 inosine 5'-phosphate pH not specified in the publication, temperature not specified in the publication Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Homo sapiens
-
-
-
1.1.1.205 Mus musculus P24547 IMPDH2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.205 HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+
-
 Mus musculus xanthosine 5'-phosphate + NADH + H+
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 0.0997
-
 curcumin pH not specified in the publication, temperature not specified in the publication Mus musculus