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Literature summary extracted from

  • Sorrentino, F.; Karioti, A.; Gratteri, P.; Rigobello, M.P.; Scutari, G.; Messori, L.; Bindoli, A.; Chioccioli, M.; Gabbiani, C.; Bergonzi, M.C.; Bilia, A.R.
    Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones (2011), Bioorg. Med. Chem., 19, 631-641.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 1,4-dihydroxyanthroquinone
-
 Rattus norvegicus
1.8.1.9 1,8-dihydroxyanthroquinone
-
 Rattus norvegicus
1.8.1.9 aloe emodin
-
 Rattus norvegicus
1.8.1.9 aloin A
-
 Rattus norvegicus
1.8.1.9 anthrone
-
 Rattus norvegicus
1.8.1.9 chrysophanol
-
 Rattus norvegicus
1.8.1.9 frangulin A
-
 Rattus norvegicus
1.8.1.9 hypericin
-
 Rattus norvegicus
1.8.1.9 physcion
-
 Rattus norvegicus
1.8.1.9 pseudohypericin strong inhibitor of isoform TrxR1 Rattus norvegicus
1.8.1.9 Rhein
-
 Rattus norvegicus
1.8.1.9 sennoside A
-
 Rattus norvegicus
1.8.1.9 sennoside B
-
 Rattus norvegicus
1.8.1.9 skyrin glucoside
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.9 cytosol isoform TrxR1 Rattus norvegicus 5829
-
1.8.1.9 mitochondrion isoform TrxR2 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+ Rattus norvegicus
-
 thioredoxin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Rattus norvegicus O89049 isoform TrxR1
-
1.8.1.9 Rattus norvegicus Q9Z0J5 isoform TrxR2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
 Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Rattus norvegicus thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
 Rattus norvegicus
1.8.1.9 TrxR1 isoform Rattus norvegicus
1.8.1.9 TrxR2 isoform Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
 Rattus norvegicus
1.8.1.9 NADPH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.9 0.0046
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus pseudohypericin
1.8.1.9 0.0079
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus pseudohypericin
1.8.1.9 0.049
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus hypericin
1.8.1.9 0.084
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus Rhein
1.8.1.9 0.123
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus Rhein
1.8.1.9 0.132
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus physcion
1.8.1.9 0.18
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus aloe emodin
1.8.1.9 0.181
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus chrysophanol
1.8.1.9 0.185
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus physcion
1.8.1.9 0.194
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus chrysophanol
1.8.1.9 0.198
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus hypericin
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus anthrone
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus 1,4-dihydroxyanthroquinone
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus 1,8-dihydroxyanthroquinone
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus aloin A
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus sennoside A
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus sennoside B
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus frangulin A
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus skyrin glucoside
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus anthrone
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus 1,4-dihydroxyanthroquinone
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus aloe emodin
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus aloin A
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus sennoside A
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus sennoside B
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus frangulin A
1.8.1.9 0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus skyrin glucoside