Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Khan, K.M.; Fatima, N.; Rasheed, M.; Jalil, S.; Ambreen, N.; Perveen, S.; Choudhary, M.I.
    1,3,4-Oxadiazole-2(3H)-thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors (2009), Bioorg. Med. Chem., 17, 7816-7822.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.1 5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Homo sapiens
3.1.4.1 5-[3-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Homo sapiens
3.1.4.1 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-thiadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Homo sapiens
3.1.4.1 5-[4-benzyloxyphenyl]-3-octyl-1,3,4-oxadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione
-
 Homo sapiens
3.1.4.1 5-[4-pyridyl]-1,3,4-oxadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione
-
 Bothrops atrox
3.1.4.1 5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione
-
 Homo sapiens
3.1.4.1 bis(1,3,4-oxadiazol-2-methyl)-5-thione
-
 Bothrops atrox
3.1.4.1 bis(1,3,4-oxadiazol-2-propyl)-5-thione
-
 Bothrops atrox
3.1.4.1 bis(1,3,4-oxadiazol-2-propyl)-5-thione
-
 Homo sapiens
3.1.4.1 bis(1,3,4-thiadiazole-2-methyl)-5-thione
-
 Bothrops atrox
3.1.4.1 EDTA
-
 Bothrops atrox
3.1.4.1 EDTA
-
 Homo sapiens
3.1.4.1 L-cysteine
-
 Bothrops atrox
3.1.4.1 L-cysteine
-
 Homo sapiens
3.1.4.1 additional information the enzyme is not inhibited by 5-[4-pyridyl]-1,3,4-oxadiazole-2(3H)-thione, 5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-octyl-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-benzyl-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-pentyl-1,3,4-oxadiazole-2(3H)-thione, 5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione, 5-diphenylmethyl-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-benzoyl-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-(2-hydroxyethyl)-1,3,4-oxadiazole-2(3H)-thione, 5-[1-naphthyl]-1,3,4-oxadiazole-2(3H)-thione, 5-phenyl-1,3,4-thiadiazole-2(3H)-thione, 5-[4-hydroxyphenyl]-3-benzyl-1,3,4-thiadiazole-2(3H)-thione, 5-[4-propoxyphenyl]-3-propyl-1,3,4-thiadiazole-2(3H)-thione, 5-diphenylmethyl-1,3,4-thiadiazole-2(3H)-thionr, 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione, and 5-[4-benzyloxyphenyl]-3-benzyl-1,3,4-thiaadiazole-2(3H)-thione Bothrops atrox
3.1.4.1 additional information the enzyme is not inhibited by bis(1,3,4-oxadiazol-2-methyl)-5-thione, 5-[4-pyridyl]-1,3,4-oxadiazole-2(3H)-thione, 5-[3-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-octyl-1,3,4-oxadiazole-2(3H)-thione, and 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-thiadiazole-2 (3H)-thione Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.1 Bothrops atrox
-
-
-
3.1.4.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.1 venom
-
 Bothrops atrox
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.1 4-nitrophenyl phenyl phosphonate + H2O
-
 Homo sapiens 4-nitrophenol + phenyl phosphonate
-
 ?
3.1.4.1 bis(4-nitrophenyl) phosphate + H2O
-
 Bothrops atrox 4-nitrophenyl phosphate + 4-nitrophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.1 NPP1
-
 Homo sapiens
3.1.4.1 NPP1
-
 Bothrops atrox
3.1.4.1 nucleotide pyrophosphatase/phosphodiesterase 1
-
 Homo sapiens
3.1.4.1 nucleotide pyrophosphatase/phosphodiesterase 1
-
 Bothrops atrox
3.1.4.1 PC-1
-
 Homo sapiens
3.1.4.1 PC-1
-
 Bothrops atrox
3.1.4.1 phosphodiesterase 1
-
 Homo sapiens
3.1.4.1 phosphodiesterase 1
-
 Bothrops atrox
3.1.4.1 plasma cell membrane glycoprotein
-
 Homo sapiens
3.1.4.1 plasma cell membrane glycoprotein
-
 Bothrops atrox

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.1 0.15
-
 bis(1,3,4-oxadiazol-2-propyl)-5-thione in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens
3.1.4.1 0.36
-
 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens
3.1.4.1 0.36
-
 5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens
3.1.4.1 0.85
-
 5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens
3.1.4.1 0.85
-
 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.1 0.06647
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-thiadiazole-2(3H)-thione
3.1.4.1 0.274
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox EDTA
3.1.4.1 0.368
-
 in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione
3.1.4.1 0.368
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione
3.1.4.1 0.39
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione
3.1.4.1 0.429
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox bis(1,3,4-oxadiazol-2-propyl)-5-thione
3.1.4.1 0.467
-
 in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens bis(1,3,4-oxadiazol-2-propyl)-5-thione
3.1.4.1 0.494
-
 in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens 5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
3.1.4.1 0.628
-
 in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens 5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
3.1.4.1 0.66
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox 5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione
3.1.4.1 0.748
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox L-cysteine
3.1.4.1 0.839
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox bis(1,3,4-thiadiazole-2-methyl)-5-thione
3.1.4.1 0.85
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox bis(1,3,4-oxadiazol-2-methyl)-5-thione
3.1.4.1 0.9
-
 in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione
3.1.4.1 0.9
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox 5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
3.1.4.1 0.96
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox 5-[4-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
3.1.4.1 0.998
-
 in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C Homo sapiens 5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione
3.1.4.1 1
-
 in Tris-HCl buffer 33 mM pH 8.8, at 37°C Bothrops atrox 5-[3-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione