Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bora-Tatar, G.; Dayangac-Erden, D.; Demir, A.S.; Dalkara, S.; Yelekci, K.; Erdem-Yurter, H.
    Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies (2009), Bioorg. Med. Chem., 17, 5219-5228.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 2,3-dihydrobenzoic acid 98% residual activity at 0.5 mM Homo sapiens
3.5.1.98 2-hydroxybutyric acid 96% residual activity at 0.5 mM Homo sapiens
3.5.1.98 3,4-Dihydroxyphenyl acetic acid 90% residual activity at 0.5 mM Homo sapiens
3.5.1.98 3-hydroxycinnamic acid 96% residual activity at 0.5 mM Homo sapiens
3.5.1.98 8-hydroxyquinoline 85% residual activity at 0.5 mM Homo sapiens
3.5.1.98 Baclofen 98% residual activity at 0.5 mM Homo sapiens
3.5.1.98 Butyric acid
-
Homo sapiens
3.5.1.98 caffeic acid 80% residual activity at 0.5 mM Homo sapiens
3.5.1.98 chlorogenic acid highly potent HDAC inhibitor, 40% residual activity at 0.5 mM Homo sapiens
3.5.1.98 Cinnamic acid 95% residual activity at 0.5 mM Homo sapiens
3.5.1.98 curcumin highly potent HDAC inhibitor, 52% residual activity at 0.5 mM Homo sapiens
3.5.1.98 D-(-)-quinic acid 96% residual activity at 0.5 mM Homo sapiens
3.5.1.98 dihydrocaffeic acid 86% residual activity at 0.5 mM Homo sapiens
3.5.1.98 ferulic acid 80% residual activity at 0.5 mM Homo sapiens
3.5.1.98 gamma-aminobutyric acid
-
Homo sapiens
3.5.1.98 indol-2-carboxylic acid 97% residual activity at 0.5 mM Homo sapiens
3.5.1.98 isobutyric acid 80% residual activity at 0.5 mM Homo sapiens
3.5.1.98 Mandelic acid 85% residual activity at 0.5 mM Homo sapiens
3.5.1.98 additional information HDAC is not inhibited by isovaleric acid, L-valine, sodium lactate, succinic acid, citric acid, benzylic acid, hippuric acid, antranilic acid (2-aminobenzoic acid), alpha-hydroxyacetonaphthone, and kojic acid Homo sapiens
3.5.1.98 phenyl butyric acid
-
Homo sapiens
3.5.1.98 phenylbutyric acid
-
Homo sapiens
3.5.1.98 propionic acid 80% residual activity at 0.5 mM Homo sapiens
3.5.1.98 salicylic acid 92% residual activity at 0.5 mM Homo sapiens
3.5.1.98 sodium butyrate
-
Homo sapiens
3.5.1.98 sodium phenylbutyrate
-
Homo sapiens
3.5.1.98 sorbic acid 91% residual activity at 0.5 mM Homo sapiens
3.5.1.98 suberoyl anilide hydroxamic acid
-
Homo sapiens
3.5.1.98 tartaric acid 90% residual activity at 0.5 mM Homo sapiens
3.5.1.98 trichostatin A
-
Homo sapiens
3.5.1.98 Valeric acid 83% residual activity at 0.5 mM Homo sapiens
3.5.1.98 Valproic acid
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.98 nucleus
-
Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens Q9BY41
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 tert-butyloxycarbonyl-L-Lys(acetyl)-7-amido-4-methylcoumarin + H2O
-
Homo sapiens tert-butyloxycarbonyl-L-Lys-7-amido-4-methylcoumarin + acetate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC8
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.98 0.00000821
-
Cinnamic acid pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.000135
-
chlorogenic acid pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.000504
-
trichostatin A pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.000539
-
curcumin pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.00247
-
suberoyl anilide hydroxamic acid pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.0028
-
phenyl butyric acid pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.00634
-
sodium phenylbutyrate pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.00819
-
gamma-aminobutyric acid pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.01084
-
caffeic acid pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.136
-
Butyric acid pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.365
-
sodium butyrate pH and temperature not specified in the publication Homo sapiens
3.5.1.98 0.564
-
Valproic acid pH and temperature not specified in the publication Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.98 0.115
-
pH and temperature not specified in the publication Homo sapiens curcumin
3.5.1.98 0.375
-
pH and temperature not specified in the publication Homo sapiens chlorogenic acid
3.5.1.98 2.54
-
pH and temperature not specified in the publication Homo sapiens caffeic acid