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Literature summary extracted from

  • Yu, G.; Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Praveen Rao, P.N.; Das, D.; Velazquez, C.A.; Suresh, M.R.; Knaus, E.E.
    Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity (2010), Bioorg. Med. Chem. Lett., 20, 896-902.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
1.13.11.34 2-[2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
1.13.11.34 2-[3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
1.13.11.34 2-[4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
1.13.11.34 3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
1.13.11.34 4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
1.13.11.34 caffeic acid micromolar 5-LOX inhibitory activity Solanum tuberosum

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Solanum tuberosum
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Solanum tuberosum
1.13.11.34 5-LOX
-
 Solanum tuberosum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.0002
-
 pH and temperature not specified in the publication Solanum tuberosum 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
1.13.11.34 0.00037
-
 pH and temperature not specified in the publication Solanum tuberosum 3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
1.13.11.34 0.00037
-
 pH and temperature not specified in the publication Solanum tuberosum 2-[3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
1.13.11.34 0.002
-
 pH and temperature not specified in the publication Solanum tuberosum 2-[2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
1.13.11.34 0.003
-
 pH and temperature not specified in the publication Solanum tuberosum 2-[4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
1.13.11.34 0.00347
-
 pH and temperature not specified in the publication Solanum tuberosum 4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
1.13.11.34 0.004
-
 pH and temperature not specified in the publication Solanum tuberosum caffeic acid