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Literature summary extracted from

  • Yao, J.; Zhang, Q.; Min, J.; He, J.; Yu, Z.
    Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers (2010), Bioorg. Med. Chem. Lett., 20, 56-59.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9 gene fabI, overexpression in Escherichia coli strain M15 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 curcumin i.e. (E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, an uncompetitive inhibition of FabI, shows antibacterial activity against Escherichia coli, sensitivity is decreased in FabI-overexpressing Escherichia coli Escherichia coli
1.3.1.9 genistein i.e. 4',5,7-trihydroxyisoflavone Escherichia coli
1.3.1.9 imperatorin i.e. 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one Escherichia coli
1.3.1.9 luteolin i.e. 3',4',5,7-tetrahydroxyflavone, uncompetitive inhibition of FabI, sensitivity is decreased in FabI-overexpressing Escherichia coli Escherichia coli
1.3.1.9 additional information MMIC50 values of the natural inhibitors, overview Escherichia coli
1.3.1.9 polydatin i.e. 3,4',5-trihydroxystilbene-3-beta-D-glucopyranoside Escherichia coli
1.3.1.9 triclosan
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Escherichia coli P0AEK4 gene fabI
-
1.3.1.9 Escherichia coli MG1655 P0AEK4 gene fabI
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 additional information activity detection via measurement of NADPH production by reduction of crotonoyl-CoA Escherichia coli ?
-
 ?
1.3.1.9 additional information activity detection via measurement of NADPH production by reduction of crotonoyl-CoA Escherichia coli MG1655 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl-ACP reductase
-
 Escherichia coli
1.3.1.9 FabI
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.9 22
-
 assay at room temperature Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.9 7.5
-
 assay at Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NAD+
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.9 additional information
-
 additional information inhibition kinetics, overview Escherichia coli
1.3.1.9 0.0071
-
 luteolin pH 7.5, 22°C Escherichia coli
1.3.1.9 0.015
-
 curcumin pH 7.5, 22°C Escherichia coli