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Literature summary extracted from

  • Pahwa, S.; Kaur, S.; Jain, R.; Roy, N.
    Structure based design of novel inhibitors for histidinol dehydrogenase from Geotrichum candidum (2010), Bioorg. Med. Chem. Lett., 20, 3972-3976.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.23 1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
-
 Geotrichum candidum
1.1.1.23 3-(1H-imidazol-4-yl)propanoic acid
-
 Geotrichum candidum
1.1.1.23 5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid i.e. RJ-278 Geotrichum candidum
1.1.1.23 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
-
 Geotrichum candidum
1.1.1.23 methyl 1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
-
 Geotrichum candidum
1.1.1.23 methyl 1-methyl-N-(phenoxycarbonyl)histidinate
-
 Geotrichum candidum
1.1.1.23 methyl 3-(1H-imidazol-4-yl)propanoate
-
 Geotrichum candidum
1.1.1.23 methyl N-(methoxycarbonyl)histidinate
-
 Geotrichum candidum
1.1.1.23 additional information screening of substrate analog inhibitors of histidinol dehydrogenase, and docking analysis of these antifungal agents, overview Geotrichum candidum

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.23 Geotrichum candidum A1BPP9 gene hisD
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.23 additional information ligand-protein interactions in the active site of GcHDH, molecular docking, overview Geotrichum candidum ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.23 homodimer structure modelling, overview Geotrichum candidum
1.1.1.23 More Geotrichum candidum HIS4 protein has HIS4A, HIS4B, and HIS4C subregions Geotrichum candidum

Synonyms

EC Number Synonyms Comment Organism
1.1.1.23 GcHDH
-
 Geotrichum candidum
1.1.1.23 HIS4 protein
-
 Geotrichum candidum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.23 0.00317
-
 pH not specified in the publication, temperature not specified in the publication Geotrichum candidum 3-(1H-imidazol-4-yl)propanoic acid
1.1.1.23 0.00356
-
 pH not specified in the publication, temperature not specified in the publication Geotrichum candidum 5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
1.1.1.23 0.0052
-
 pH not specified in the publication, temperature not specified in the publication Geotrichum candidum methyl 3-(1H-imidazol-4-yl)propanoate
1.1.1.23 0.0106
-
 pH not specified in the publication, temperature not specified in the publication Geotrichum candidum methyl N-(methoxycarbonyl)histidinate
1.1.1.23 0.0242
-
 pH not specified in the publication, temperature not specified in the publication Geotrichum candidum 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
1.1.1.23 0.0293
-
 pH not specified in the publication, temperature not specified in the publication Geotrichum candidum methyl 1-methyl-N-(phenoxycarbonyl)histidinate
1.1.1.23 0.0587
-
 pH not specified in the publication, temperature not specified in the publication Geotrichum candidum 1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
1.1.1.23 0.1222
-
 pH not specified in the publication, temperature not specified in the publication Geotrichum candidum methyl 1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate

General Information

EC Number General Information Comment Organism
1.1.1.23 metabolism histidinol dehydrogenase mediates the final step in the histidine biosynthetic pathway Geotrichum candidum