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Literature summary extracted from

  • Chetan, B.; Bunha, M.; Jagrat, M.; Sinha, B.N.; Saiko, P.; Graser, G.; Szekeres, T.; Raman, G.; Rajendran, P.; Moorthy, D.; Basu, A.; Jayaprakash, V.
    Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity (2010), Bioorg. Med. Chem. Lett., 20, 3906-3910.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 (2E)-3-[4-([[2-(3a,7a-dihydro-1H-indol-3-yl)ethyl](2-hydroxyethyl)amino]methyl)phenyl]-N-hydroxyprop-2-enamide
-
 Homo sapiens
3.5.1.98 4-[[(2E)-2-(2-chlorobenzylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide
-
 Homo sapiens
3.5.1.98 4-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide inactivates HDAC8 preferentially over HDAC1 Homo sapiens
3.5.1.98 4-[[(2E)-2-(anthracen-9-ylmethylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide
-
 Homo sapiens
3.5.1.98 MS-275
-
 Homo sapiens
3.5.1.98 N-hydroxy-4-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide inactivates HDAC8 preferentially over HDAC1 Homo sapiens
3.5.1.98 N-hydroxy-4-[[(2E)-2-(4-methylbenzylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide
-
 Homo sapiens
3.5.1.98 N-hydroxy-4-[[(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide
-
 Homo sapiens
3.5.1.98 NVP-LAQ824
-
 Homo sapiens
3.5.1.98 suberoyl anilide hydroxamic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens Q9BY41
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 HCT-116 cell
-
 Homo sapiens
-
3.5.1.98 NCI-H460 cell
-
 Homo sapiens
-
3.5.1.98 U-251 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC8
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.98 0.000045
-
 pH and temperature not specified in the publication Homo sapiens (2E)-3-[4-([[2-(3a,7a-dihydro-1H-indol-3-yl)ethyl](2-hydroxyethyl)amino]methyl)phenyl]-N-hydroxyprop-2-enamide
3.5.1.98 0.03367
-
 pH and temperature not specified in the publication Homo sapiens N-hydroxy-4-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide
3.5.1.98 0.04316
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide