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Literature summary extracted from

  • Jung, H.A.; Oh, S.H.; Choi, J.S.
    Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity (2010), Bioorg. Med. Chem. Lett., 20, 3211-3215.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.46 7-phloroethol significant BACE1 inhibition in a dose-dependent manner Homo sapiens
3.4.23.46 dieckol significant BACE1 inhibition in a dose-dependent manner Homo sapiens
3.4.23.46 dioxinodehydroeckol significant BACE1 inhibition in a dose-dependent manner Homo sapiens
3.4.23.46 eckol significant BACE1 inhibition in a dose-dependent manner Homo sapiens
3.4.23.46 phlorofurofucoeckol-A significant BACE1 inhibition in a dose-dependent manner Homo sapiens
3.4.23.46 phloroglucinol significant BACE1 inhibition in a dose-dependent manner Homo sapiens
3.4.23.46 quercetin significant BACE1 inhibition in a dose-dependent manner Homo sapiens
3.4.23.46 triphloroethol A significant BACE1 inhibition in a dose-dependent manner Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.46 amyloid precursor protein + H2O Homo sapiens
-
 fragments of amyloid precursor protein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.46 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.46 amyloid precursor protein + H2O
-
 Homo sapiens fragments of amyloid precursor protein
-
 ?
3.4.23.46 rhodamine-EVNLDAEFK-quencher + H2O
-
 Homo sapiens rhodamine-EVNL + DAEFK-quencher
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.46 BACE1
-
 Homo sapiens
3.4.23.46 beta-secretase
-
 Homo sapiens
3.4.23.46 beta-site amyloid precursor protein cleaving enzyme
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.23.46 0.00213
-
 in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens phlorofurofucoeckol-A
3.4.23.46 0.00221
-
 in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens dieckol
3.4.23.46 0.00535
-
 in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens dioxinodehydroeckol
3.4.23.46 0.00859
-
 in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens 7-phloroethol
3.4.23.46 0.01082
-
 in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens quercetin
3.4.23.46 0.01168
-
 in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens triphloroethol A
3.4.23.46 0.0122
-
 in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens eckol
3.4.23.46 0.03647
-
 in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens phloroglucinol