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Literature summary extracted from

  • Aparoy, P.; Kumar Reddy, K.; Kalangi, S.K.; Chandramohan Reddy, T.; Reddanna, P.
    Pharmacophore modeling and virtual screening for designing potential 5-lipoxygenase inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 1013-1018.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 (2E)-3-(3,4-dihydroxyphenyl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one
-
 Solanum tuberosum
1.13.11.34 (2Z)-2-[4-(acetylamino)phenyl]-3-[4-(methylsulfonyl)phenyl]prop-2-enoic acid
-
 Solanum tuberosum
1.13.11.34 1-(3-hydroxyphenyl)-3-[4-(methylsulfonyl)phenyl]prop-2-yn-1-one
-
 Solanum tuberosum
1.13.11.34 1-(4-chlorobenzyl)-2-[2,2-dimethyl-3-(1H-tetrazol-5-yl)propyl]-4-methyl-6-[2-(5-phenylpyridin-2-yl)ethyl]-2,2a,4,5-tetrahydro-1H-thiopyrano[2,3,4-cd]indole
-
 Solanum tuberosum
1.13.11.34 1-(7-tert-butyl-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)butan-1-one
-
 Solanum tuberosum
1.13.11.34 1-(8-tert-butyl-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)-4-cyclopropylbutan-1-one
-
 Solanum tuberosum
1.13.11.34 1-(difluoromethyl)-5-[[2-(methylsulfonyl)phenyl]ethynyl]pyridin-2(1H)-one
-
 Solanum tuberosum
1.13.11.34 2-[(1-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)ethynyl]benzenesulfonamide
-
 Solanum tuberosum
1.13.11.34 3-[[3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole
-
 Solanum tuberosum
1.13.11.34 4-(furan-3-yl)-7-[[6-(4-hydroxytetrahydro-2H-pyran-4-yl)pyridin-2-yl]methoxy]naphthalene-2-carbonitrile
-
 Solanum tuberosum
1.13.11.34 4-methoxy-4-[3-(naphthalen-2-ylmethoxy)phenyl]tetrahydro-2H-pyran
-
 Solanum tuberosum
1.13.11.34 4-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-2,2a,4,5-tetrahydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-N-(methylsulfonyl)butanamide
-
 Solanum tuberosum
1.13.11.34 4-[5-(1H-indol-3-yl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide
-
 Solanum tuberosum
1.13.11.34 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
 Solanum tuberosum
1.13.11.34 5-(2-[[3-(trifluoromethyl)phenyl]amino]phenyl)-1,3,4-oxadiazole-2(3H)-thione
-
 Solanum tuberosum
1.13.11.34 5-(7-tert-butyl-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-5-oxopentanenitrile
-
 Solanum tuberosum
1.13.11.34 6-[[3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy]methyl]-1-methylquinolin-2(1H)-one
-
 Solanum tuberosum
1.13.11.34 7-(4-methylphenyl)-6-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-pyrrolizine
-
 Solanum tuberosum
1.13.11.34 7-tert-butyl-N-ethyl-N,3,3-trimethyl-2,3-dihydro-1-benzofuran-5-carboxamide
-
 Solanum tuberosum
1.13.11.34 7-[[3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl]oxy]-4-phenylnaphtho[2,3-c]furan-1(3H)-one
-
 Solanum tuberosum
1.13.11.34 7-[[3-fluoro-5-(3-hydroxy-6,8-dioxabicyclo[3.2.1]oct-3-yl)phenoxy]methyl]-4-(furan-3-yl)quinoline-2-carbonitrile
-
 Solanum tuberosum
1.13.11.34 N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
-
 Solanum tuberosum
1.13.11.34 N-[5-(4-fluorophenoxy)thiophen-2-yl]methanesulfonamide
-
 Solanum tuberosum
1.13.11.34 [2-[(1S,8aR)-2-formyl-5,5,8a-trimethyldecahydronaphthalen-1-yl]ethylidene]propanedial
-
 Solanum tuberosum

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Solanum tuberosum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 tuber
-
 Solanum tuberosum
-

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Solanum tuberosum
1.13.11.34 5-LOX
-
 Solanum tuberosum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.000003
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 3-[[3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole
1.13.11.34 0.00001
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 4-methoxy-4-[3-(naphthalen-2-ylmethoxy)phenyl]tetrahydro-2H-pyran
1.13.11.34 0.000014
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 7-[[3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl]oxy]-4-phenylnaphtho[2,3-c]furan-1(3H)-one
1.13.11.34 0.000015
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 4-(furan-3-yl)-7-[[6-(4-hydroxytetrahydro-2H-pyran-4-yl)pyridin-2-yl]methoxy]naphthalene-2-carbonitrile
1.13.11.34 0.000016
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 1-(4-chlorobenzyl)-2-[2,2-dimethyl-3-(1H-tetrazol-5-yl)propyl]-4-methyl-6-[2-(5-phenylpyridin-2-yl)ethyl]-2,2a,4,5-tetrahydro-1H-thiopyrano[2,3,4-cd]indole
1.13.11.34 0.000027
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 7-[[3-fluoro-5-(3-hydroxy-6,8-dioxabicyclo[3.2.1]oct-3-yl)phenoxy]methyl]-4-(furan-3-yl)quinoline-2-carbonitrile
1.13.11.34 0.000036
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 4-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-2,2a,4,5-tetrahydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-N-(methylsulfonyl)butanamide
1.13.11.34 0.00004
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum (2E)-3-(3,4-dihydroxyphenyl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one
1.13.11.34 0.00011
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum (2Z)-2-[4-(acetylamino)phenyl]-3-[4-(methylsulfonyl)phenyl]prop-2-enoic acid
1.13.11.34 0.00013
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum N-[5-(4-fluorophenoxy)thiophen-2-yl]methanesulfonamide
1.13.11.34 0.0003
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 1-(3-hydroxyphenyl)-3-[4-(methylsulfonyl)phenyl]prop-2-yn-1-one
1.13.11.34 0.00033
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 6-[[3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy]methyl]-1-methylquinolin-2(1H)-one
1.13.11.34 0.00077
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 5-(2-[[3-(trifluoromethyl)phenyl]amino]phenyl)-1,3,4-oxadiazole-2(3H)-thione
1.13.11.34 0.0034
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 1-(difluoromethyl)-5-[[2-(methylsulfonyl)phenyl]ethynyl]pyridin-2(1H)-one
1.13.11.34 0.006
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 5-(7-tert-butyl-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-5-oxopentanenitrile
1.13.11.34 0.0075
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum [2-[(1S,8aR)-2-formyl-5,5,8a-trimethyldecahydronaphthalen-1-yl]ethylidene]propanedial
1.13.11.34 0.008
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 1-(8-tert-butyl-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)-4-cyclopropylbutan-1-one
1.13.11.34 0.0085
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 1-(7-tert-butyl-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)butan-1-one
1.13.11.34 0.01
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
1.13.11.34 0.01
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
1.13.11.34 0.01
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 2-[(1-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)ethynyl]benzenesulfonamide
1.13.11.34 0.01
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 7-(4-methylphenyl)-6-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-pyrrolizine
1.13.11.34 0.022
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 7-tert-butyl-N-ethyl-N,3,3-trimethyl-2,3-dihydro-1-benzofuran-5-carboxamide
1.13.11.34 0.041
-
 in 100 mM phosphate buffer, pH 6.3, 25°C Solanum tuberosum 4-[5-(1H-indol-3-yl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide