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Literature summary extracted from

  • Wagner, C.; Sudati, J.H.; Nogueira, C.W.; Rocha, J.B.
    In vivo and in vitro inhibition of mice thioredoxin reductase by methylmercury (2010), Biometals, 23, 1171-1177.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 methylmercury a single administration of methylmercury (1, 5, and 10 mg/kg) causes a marked inhibition of kidney TrxR activity, while significant inhibition is observed in the liver 24 h after exposure to 5 and 10 mg/kg. In the brain, methylmercury does not inhibit TrxR activity. Methylmercury can bind to selenocysteine residues present in the catalytic site of TrxR, in turn causing enzyme inhibition that can compromise the redox state of cells Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+ Mus musculus
-
 thioredoxin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 brain
-
 Mus musculus
-
1.8.1.9 kidney
-
 Mus musculus
-
1.8.1.9 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Mus musculus thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
 Mus musculus
1.8.1.9 TrxR
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
 Mus musculus
1.8.1.9 NADPH
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.9 0.0000171
-
 TrxR from liver, pH and temperature not specified in the publication Mus musculus methylmercury
1.8.1.9 0.000078
-
 TrxR from kidney, pH and temperature not specified in the publication Mus musculus methylmercury
1.8.1.9 0.000158
-
 TrxR from brain, pH and temperature not specified in the publication Mus musculus methylmercury