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Literature summary extracted from

  • Lee, Y.S.; Kim, S.H.; Jung, S.H.; Kim, J.K.; Pan, C.H.; Lim, S.S.
    Aldose reductase inhibitory compounds from Glycyrrhiza uralensis (2010), Biol. Pharm. Bull., 33, 917-921.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
-
 Homo sapiens
1.1.1.21 (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
-
 Rattus norvegicus
1.1.1.21 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one a gamma,gamma-dimethylallyl type prenylated isoflavonoid Homo sapiens
1.1.1.21 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one a gamma,gamma-dimethylallyl type prenylated isoflavonoid Rattus norvegicus
1.1.1.21 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one a gamma,gamma-dimethylallyl type prenylated isoflavonoid Homo sapiens
1.1.1.21 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one a gamma,gamma-dimethylallyl type prenylated isoflavonoid Rattus norvegicus
1.1.1.21 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol a gamma,gamma-dimethylallyl type prenylated isoflavonoid Homo sapiens
1.1.1.21 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol a gamma,gamma-dimethylallyl type prenylated isoflavonoid Rattus norvegicus
1.1.1.21 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol a gamma,gamma-dimethylallyl type prenylated isoflavonoid Homo sapiens
1.1.1.21 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol a gamma,gamma-dimethylallyl type prenylated isoflavonoid Rattus norvegicus
1.1.1.21 epalrestat
-
 Homo sapiens
1.1.1.21 epalrestat
-
 Rattus norvegicus
1.1.1.21 isoliquiritigenin
-
 Homo sapiens
1.1.1.21 isoliquiritigenin
-
 Rattus norvegicus
1.1.1.21 liquiritigenin
-
 Homo sapiens
1.1.1.21 liquiritigenin
-
 Rattus norvegicus
1.1.1.21 additional information identification of inhibitory compounds from Glycyrrhiza uralensis, overview Homo sapiens
1.1.1.21 additional information identification of inhibitory compounds from Glycyrrhiza uralensis, overview. Inhibitory effect of the compounds on the sorbitol accumulation in rat lenses incubated with high glucose Rattus norvegicus
1.1.1.21 Myricitrin
-
 Homo sapiens
1.1.1.21 Myricitrin
-
 Rattus norvegicus
1.1.1.21 quercetin
-
 Homo sapiens
1.1.1.21 quercetin
-
 Rattus norvegicus
1.1.1.21 quercitrin
-
 Homo sapiens
1.1.1.21 quercitrin
-
 Rattus norvegicus
1.1.1.21 semilicoisoflavone B contains a gamma,gamma-dimethylchromene ring on the aromatic ring Homo sapiens
1.1.1.21 semilicoisoflavone B contains a gamma,gamma-dimethylchromene ring on the aromatic ring Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+ Homo sapiens
-
 DL-glycerol + NADP+
-
 ?
1.1.1.21 DL-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 DL-glycerol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 commercial preparation recombinant enzyme Homo sapiens
-
1.1.1.21 lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens DL-glycerol + NADP+
-
 ?
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus DL-glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Homo sapiens
1.1.1.21 aldose reductase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.21 37
-
 assay at Homo sapiens
1.1.1.21 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.21 6.2
-
 assay at Homo sapiens
1.1.1.21 7
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Homo sapiens
1.1.1.21 NADPH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.0018
-
 pH 7.0, 37°C Rattus norvegicus semilicoisoflavone B
1.1.1.21 0.002
-
 pH 7.0, 37°C Rattus norvegicus liquiritigenin
1.1.1.21 0.0025
-
 pH 7.0, 37°C Rattus norvegicus quercetin
1.1.1.21 0.0034
-
 pH 7.0, 37°C Rattus norvegicus isoliquiritigenin
1.1.1.21 0.0106
-
 pH 6.2, 37°C Homo sapiens semilicoisoflavone B
1.1.1.21 0.0127
-
 pH 7.0, 37°C Homo sapiens quercetin
1.1.1.21 0.0219
-
 pH 7.0, 37°C Homo sapiens liquiritigenin
1.1.1.21 0.0275
-
 pH 7.0, 37°C Homo sapiens isoliquiritigenin
1.1.1.21 0.0285
-
 pH 7.0, 37°C Rattus norvegicus 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
1.1.1.21 0.0427
-
 pH 7.0, 37°C Rattus norvegicus 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
1.1.1.21 0.0624
-
 pH 7.0, 37°C Rattus norvegicus 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
1.1.1.21 0.0765
-
 pH 7.0, 37°C Homo sapiens 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
1.1.1.21 0.0963
-
 pH 7.0, 37°C Rattus norvegicus (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
1.1.1.21 0.0995
-
 pH 7.0, 37°C Rattus norvegicus 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
1.1.1.21 0.1306
-
 pH 7.0, 37°C Homo sapiens 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
1.1.1.21 0.1762
-
 pH 7.0, 37°C Homo sapiens 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
1.1.1.21 0.2572
-
 pH 7.0, 37°C Homo sapiens (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
1.1.1.21 0.2808
-
 pH 7.0, 37°C Homo sapiens 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one