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Literature summary extracted from

  • Malnar, M.; Kosicek, M.; Mitterreiter, S.; Omerbasic, D.; Lichtenthaler, S.F.; Goate, A.; Hecimovic, S.
    Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface its increased processing through the beta-secretase pathway (2010), Biochim. Biophys. Acta, 1802, 682-691.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.46 beta-amyloid precursor protein + H2O Cricetulus griseus the loss of Niemann-Pick type C1 increases beta-secretase cleavage of beta-amyloid precursor protein fragments of amyloid precursor protein
-
 ?
3.4.23.46 beta-amyloid precursor protein + H2O Cricetulus griseus
-
 fragments of beta-amyloid precursor protein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.46 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.46 CHO cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.46 beta-amyloid precursor protein + H2O the loss of Niemann-Pick type C1 increases beta-secretase cleavage of beta-amyloid precursor protein Cricetulus griseus fragments of amyloid precursor protein
-
 ?
3.4.23.46 beta-amyloid precursor protein + H2O
-
 Cricetulus griseus fragments of beta-amyloid precursor protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.46 BACE-1
-
 Cricetulus griseus
3.4.23.46 BACE1
-
 Cricetulus griseus
3.4.23.46 beta-secretase
-
 Cricetulus griseus

Expression

EC Number Organism Comment Expression
3.4.23.46 Cricetulus griseus the loss of Niemann-Pick type C1 affects beta-amyloid generation by increasing beta-secretase cleavage up