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Literature summary extracted from

  • Sheeran, F.L.; Rydstroem, J.; Shakhparonov, M.I.; Pestov, N.B.; Pepe, S.
    Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium (2010), Biochim. Biophys. Acta, 1797, 1138-1148.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.1.2 H2O2 136% increase of activity at 0.5 mM Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.1.2 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole 34% residual activity at 1 mM Homo sapiens
1.6.1.2 palmitoyl CoA specifically interferes with Nnt activity by competition with NADPH-binding, 20% residual activity at 1 mM Homo sapiens
1.6.1.2 S-nitrosoglutathione 100% inhibition at 3 mM or higher concentration Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.1.2 mitochondrion inner mitochondrial membrane Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.6.1.2 110000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.1.2 NADPH + NAD+ Homo sapiens
-
NADP+ + NADH
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.6.1.2 Homo sapiens Q13423
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.1.2 Nnt is purified using an immunocapture bead matrix Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.1.2 myocardium
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.1.2 NADPH + 3-acetylpyridine adenine dinucleotide
-
Homo sapiens NADP+ + reduced 3-acetylpyridine adenine dinucleotide
-
?
1.6.1.2 NADPH + NAD+
-
Homo sapiens NADP+ + NADH
-
?

Synonyms

EC Number Synonyms Comment Organism
1.6.1.2 NADPH transhydrogenase
-
Homo sapiens
1.6.1.2 NNT
-
Homo sapiens

Expression

EC Number Organism Comment Expression
1.6.1.2 Homo sapiens Nnt activity is reduced by 18% in the heart failure down