EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.6.1.2 | H2O2 | 136% increase of activity at 0.5 mM | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.6.1.2 | 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole | 34% residual activity at 1 mM | Homo sapiens | |
1.6.1.2 | palmitoyl CoA | specifically interferes with Nnt activity by competition with NADPH-binding, 20% residual activity at 1 mM | Homo sapiens | |
1.6.1.2 | S-nitrosoglutathione | 100% inhibition at 3 mM or higher concentration | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.6.1.2 | mitochondrion | inner mitochondrial membrane | Homo sapiens | 5739 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.6.1.2 | 110000 | - |
SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.1.2 | NADPH + NAD+ | Homo sapiens | - |
NADP+ + NADH | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.1.2 | Homo sapiens | Q13423 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.6.1.2 | Nnt is purified using an immunocapture bead matrix | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.1.2 | myocardium | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.1.2 | NADPH + 3-acetylpyridine adenine dinucleotide | - |
Homo sapiens | NADP+ + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
1.6.1.2 | NADPH + NAD+ | - |
Homo sapiens | NADP+ + NADH | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.6.1.2 | NADPH transhydrogenase | - |
Homo sapiens |
1.6.1.2 | NNT | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.6.1.2 | Homo sapiens | Nnt activity is reduced by 18% in the heart failure | down |