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Literature summary extracted from

  • Binger, K.J.; Griffin, M.D.; Heinemann, S.H.; Howlett, G.J.
    Methionine-oxidized amyloid fibrils are poor substrates for human methionine sulfoxide reductases A and B2 (2010), Biochemistry, 49, 2981-2983.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.12
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin Homo sapiens
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.12
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin
-
 Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 additional information methionine-oxidized amyloid fibrils (methionine-oxidized monomer and fibrillar apoC-II) are poor substrates for human methionine sulfoxide reductase B2. At Msr concentrations of more than 0.0005 mM, approximately 90% of monomeric MetO-apoCII is reduced. In contrast, at 0.0005 mM Msr, only 35% of fibrillar MetO-apoC-II is reduced, which increased to only 37% after incubation with a 4fold higher enzyme concentration Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 methionine sulfoxide reductase B2
-
 Homo sapiens
1.8.4.12 MsrB2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.12 thioredoxin
-
 Homo sapiens