EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.6.5.2 | 3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one) | - |
Homo sapiens | |
1.6.5.2 | 3,3'-methanediylbis(4-hydroxy-5-methoxy-2H-chromen-2-one) | - |
Homo sapiens | |
1.6.5.2 | 3,3'-methanediylbis(4-hydroxy-6,7-dimethoxy-2H-chromen-2-one) | - |
Homo sapiens | |
1.6.5.2 | 3,3'-methanediylbis(4-hydroxy-6,7-dimethyl-2H-chromen-2-one) | - |
Homo sapiens | |
1.6.5.2 | 3,3'-methanediylbis(4-hydroxy-6-methoxy-2H-chromen-2-one) | - |
Homo sapiens | |
1.6.5.2 | 3,3'-methanediylbis(4-hydroxy-7,8-dimethyl-2H-chromen-2-one) | - |
Homo sapiens | |
1.6.5.2 | 3,3'-methanediylbis(4-hydroxy-7-methoxy-2H-chromen-2-one) | - |
Homo sapiens | |
1.6.5.2 | 3-(3,4-dimethylbenzyl)-4-hydroxy-6,7-dimethyl-2H-chromen-2-one | - |
Homo sapiens | |
1.6.5.2 | 4-hydroxy-3-(naphthalen-1-yl)cyclohepta[h]chromen-2(7H)-one | - |
Homo sapiens | |
1.6.5.2 | 4-hydroxy-3-(naphthalen-2-yl)cyclohepta[h]chromen-2(7H)-one | - |
Homo sapiens | |
1.6.5.2 | 4-hydroxy-3-phenylcyclohepta[h]chromen-2(7H)-one | - |
Homo sapiens | |
1.6.5.2 | 4-hydroxy-6,7-dimethyl-3-(naphthalen-1-yl)-2H-chromen-2-one | - |
Homo sapiens | |
1.6.5.2 | 4-hydroxy-6,7-dimethyl-3-(naphthalen-2-yl)-2H-chromen-2-one | - |
Homo sapiens | |
1.6.5.2 | 4-hydroxy-6,7-dimethyl-3-phenyl-2H-chromen-2-one | - |
Homo sapiens | |
1.6.5.2 | dicoumarol | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.5.2 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.5.2 | A-549 cell | - |
Homo sapiens | - |
1.6.5.2 | HT-29 cell | - |
Homo sapiens | - |
1.6.5.2 | MiaPaCa-2 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.5.2 | menadione + NADH | - |
Homo sapiens | reduced menadione + NAD+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.6.5.2 | DT-diaphorase | - |
Homo sapiens |
1.6.5.2 | EC 1.6.99.2 | formerly | Homo sapiens |
1.6.5.2 | NAD(P)H quinone oxidoreductase | - |
Homo sapiens |
1.6.5.2 | NQO1 | - |
Homo sapiens |
1.6.5.2 | quinone reductase 1 | - |
Homo sapiens |
1.6.5.2 | Vitamin K reductase | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.6.5.2 | FAD | - |
Homo sapiens | |
1.6.5.2 | NADH | - |
Homo sapiens | |
1.6.5.2 | NADPH | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.6.5.2 | 0.00000041 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-6,7-dimethyl-2H-chromen-2-one) | |
1.6.5.2 | 0.00000042 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-7,8-dimethyl-2H-chromen-2-one) | |
1.6.5.2 | 0.0000022 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-3-(naphthalen-2-yl)cyclohepta[h]chromen-2(7H)-one | |
1.6.5.2 | 0.0000025 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-6,7-dimethyl-3-(naphthalen-2-yl)-2H-chromen-2-one | |
1.6.5.2 | 0.0000026 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one) | |
1.6.5.2 | 0.0000028 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-5-methoxy-2H-chromen-2-one) | |
1.6.5.2 | 0.000006 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-7-methoxy-2H-chromen-2-one) | |
1.6.5.2 | 0.0000063 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-3-(naphthalen-1-yl)cyclohepta[h]chromen-2(7H)-one | |
1.6.5.2 | 0.0000077 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-6,7-dimethyl-3-(naphthalen-1-yl)-2H-chromen-2-one | |
1.6.5.2 | 0.0000099 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3-(3,4-dimethylbenzyl)-4-hydroxy-6,7-dimethyl-2H-chromen-2-one | |
1.6.5.2 | 0.000011 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-6-methoxy-2H-chromen-2-one) | |
1.6.5.2 | 0.000035 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-3-phenylcyclohepta[h]chromen-2(7H)-one | |
1.6.5.2 | 0.000038 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-5-methoxy-2H-chromen-2-one) | |
1.6.5.2 | 0.000039 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-6,7-dimethyl-3-phenyl-2H-chromen-2-one | |
1.6.5.2 | 0.000062 | - |
without bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-6,7-dimethoxy-2H-chromen-2-one) | |
1.6.5.2 | 0.000149 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-7,8-dimethyl-2H-chromen-2-one) | |
1.6.5.2 | 0.000167 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-6,7-dimethyl-3-(naphthalen-2-yl)-2H-chromen-2-one | |
1.6.5.2 | 0.000192 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3-(3,4-dimethylbenzyl)-4-hydroxy-6,7-dimethyl-2H-chromen-2-one | |
1.6.5.2 | 0.000225 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-3-(naphthalen-2-yl)cyclohepta[h]chromen-2(7H)-one | |
1.6.5.2 | 0.000233 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-6,7-dimethyl-2H-chromen-2-one) | |
1.6.5.2 | 0.000404 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one) | |
1.6.5.2 | 0.00045 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-3-(naphthalen-1-yl)cyclohepta[h]chromen-2(7H)-one | |
1.6.5.2 | 0.00066 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-6,7-dimethyl-3-phenyl-2H-chromen-2-one | |
1.6.5.2 | 0.00079 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-7-methoxy-2H-chromen-2-one) | |
1.6.5.2 | 0.00088 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-3-phenylcyclohepta[h]chromen-2(7H)-one | |
1.6.5.2 | 0.001095 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 4-hydroxy-6,7-dimethyl-3-(naphthalen-1-yl)-2H-chromen-2-one | |
1.6.5.2 | 0.001497 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-6,7-dimethoxy-2H-chromen-2-one) | |
1.6.5.2 | 0.0033 | - |
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C | Homo sapiens | 3,3'-methanediylbis(4-hydroxy-6-methoxy-2H-chromen-2-one) |